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Phylogenetic and structural analyses of equine rotaviruses : three possible geographically related lineages

Abstract
The structural analyses revealed that the aa substitutions in VP7 are in the antigenic sites and in the VP7:VP6 interaction region. In accordance, most of the aa changes in VP6 are in the top of the protein involving antigenic and VP7:VP6 interaction sites. Interestingly, the structural analyses of VP8* showed a few aa differences in the antigenic sites and, all equine P[12] shown the same conserved aa sequence in VP8* pocket, only observed in P[12] [ver mas...]
The structural analyses revealed that the aa substitutions in VP7 are in the antigenic sites and in the VP7:VP6 interaction region. In accordance, most of the aa changes in VP6 are in the top of the protein involving antigenic and VP7:VP6 interaction sites. Interestingly, the structural analyses of VP8* showed a few aa differences in the antigenic sites and, all equine P[12] shown the same conserved aa sequence in VP8* pocket, only observed in P[12] genotype. Our study suggest the existence of geographically related equine RVA lineages and, describe the aa configuration of the VP8* pocket. [Cerrar]
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Author
Miño, Samuel;   Parreño, Viviana;   Barrandeguy, Maria Edith;  
Fuente
Journal of equine veterinary science 39 : S23eS25
Date
2016
ISSN
0737-0806
URI
http://hdl.handle.net/20.500.12123/1015
http://www.j-evs.com/article/S0737-0806(16)00086-1/pdf
DOI
http://dx.doi.org/10.1016/j.jevs.2016.02.055
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pdf
Tipo de documento
article
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Excepto donde se diga explicitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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