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A new gnotobiotic pig model of P[6] human rotavirus infection and disease for preclinical evaluation of rotavirus vaccines
Nyblade, Charlotte; Hensley, Casey; Parreño, Gladys Viviana; Zhou, Peng; Frazier, Maggie; Frazier, Annie; Ramesh, Ashwin; Lei, Shaohua; Degiuseppe, Juan Ignacio; Tan, Ming; Yuan, Lijuan (MDPI, 2022-12)Human rotavirus (HRV) is a leading cause of gastroenteritis in children under 5 years of age. Licensed vaccines containing G1P[8] and G1-4P[8] strains are less efficacious against newly emerging P[6] strains, indicating ... -
A new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farms
Vega, Celina Guadalupe; Bok, Marina; Ebinger, Maren; Rocha, Lucía Alejandra; Rivolta, Alejandra Antonella; González Thomas, Valeria; Muntadas, Pilar; D’Aloia, Ricardo; Pinto, Verónica; Parreño, Viviana; Wigdorovitz, Andres (BMC, 2020-07)Background: Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination ... -
A novel MHC-II targeted BVDV subunit vaccine induces a neutralizing immunological response in guinea pigs and cattle
Bellido, Demian; Baztarrica, Josefina; Rocha, Lucía Alejandra; Pecora, Andrea; Acosta, Mario; Escribano, José M.; Parreño, Gladys; Wigdorovitz, Andres (Wiley, 2021-11)Bovine viral diarrhoea virus (BVDV) is a major cause of economic loss in the cattle industry, worldwide. Infection results in reduced productive performance, growth retardation, reduced milk production and increased ... -
A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity
Salmen, Wilhelm; Hu, Liya; Bok, Marina; Chaimongkol, Natthawan; Ettayebi, Khalil; Sosnovtsev, Stanislav V.; Soni, Kaundal; Ayyar, B. Vijayalakshmi; Shanker, Sreejesh; Neill, Frederick H.; Sankaran, Banumathi; Atmar, Robert L.; Estes, Mary K.; Green, Kim Y.; Parreño, Gladys Viviana; Prasad, B. V. Venkataram (Nature Publishing Group, 2023-10)Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus ... -
An indirect ELISA validated as diagnostic and vaccines quality control tool for bovine parainfluenza virus TYPE 3 (BPIV3)
Odeon, Maria Mercedes; Maidana, Silvina Soledad; Ferrecio, Carola Maria; Grazziotto, Noelia Magali; Pisano, Eddie; Alvarez, Irene; Rocha, Lucía Alejandra; Parreño, Gladys Viviana; Romera, Sonia Alejandra (CNRS (Francia), 2021-07)Serological assays, including enzyme-linked immunosorbent assays (ELISA), provide a useful tool to screen animals for the presence of antibodies (Abs) against a wide range of infectious agents (including viruses that cause ... -
Anti-VP6 VHH : an experimental treatment for rotavirus A-associated disease
Maffey, Lucia; Vega, Celina Guadalupe; Miño, Samuel; Garaicoechea, Lorena Laura; Parreño, Viviana (2016)Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific llama-derived heavy chain antibody ... -
Assessment of Influential Factors for Scours Associated with Cryptosporidium sp., Rotavirus and Coronavirus in Calves from Argentinean Dairy Farms
Bertoni, Emiliano Agustín; Barragán, Adrián A.; Bok, Marina; Vega, Celina Guadalupe; Martinez, Gabriela Marcela; Gil, José F.; Cimino, Rubén Oscar; Parreño, Gladys (MDPI, 2021-09)Scours is the most common disease in dairy calves, and it is a multifactorial syndrome complex. Cryptosporidium sp. (C. sp.), rotavirus group A (RVA), and bovine coronavirus (BCoV) are the three main pathogens associated ... -
Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
Castells, Matias; Giannitti, Federico; Caffarena, Rubén Darío; Casaux, María Laura; Schild, Carlos; Castells, Daniel; Riet‑Correa, Franklin; Victoria, Matias; Parreño, Gladys; Colina, Rodney (Springer, 2019-11)Bovine coronavirus (BCoV) is a recognized cause of severe neonatal calf diarrhea, with a negative impact on animal welfare, leading to economic losses to the livestock industry. Cattle production is one of the most important ... -
Bovine rotavirus strains circulating in beef and dairy herds in Argentina from 2004 to 2010
Badaracco, Alejandra; Garaicoechea, Lorena Laura; Rodriguez, Daniela Vanesa; Louge Uriarte, Enrique Leopoldo; Odeon, Anselmo Carlos; Bilbao, Gladys; Galarza, Roxana Ivon; Abdala, Alejandro Ariel; Fernandez, Fernando Maria; Parreño, Gladys Viviana (Elsevier, 2012-08-17)Bovine Group A Rotavirus (RVA) is one of the main causes of neonatal calf diarrhea worldwide. The present study reports the genotyping of bovine RVA strains circulating in Argentinean cattle from 2004 to 2010. Additionally, ... -
Combined live oral priming and intramuscular boosting regimen with Rotarix® and a nanoparticle-based trivalent rotavirus vaccine evaluated in gnotobiotic pig models of G4P[6] and G1P[8] human rotavirus infection
Hensley, Casey; Nyblade, Charlotte; Zhou, Peng; Parreño, Gladys Viviana; Ramesh, Ashwin; Frazier, Annie; Frazier, Maggie; Garrison, Sarah; Fantasia-Davis, Ariana; Cai, Ruiqing; Huang, Peng-Wei; Xia, Ming; Tan, Ming; Yuan, Lijuan (MDPI, 2023-05)Human rotavirus (HRV) is the causative agent of severe dehydrating diarrhea in children under the age of five, resulting in up to 215,000 deaths each year. These deaths almost exclusively occur in low- and middle-income ... -
Detection, risk factors and molecular diversity of norovirus GIII in cattle in Uruguay
Castells, Matias; Caffarena, Rubén Darío; Casaux, María Laura; Schild, Carlos; Castells, Felipe; Castells, Daniel; Victoria, Matías; Riet‑Correa, Franklin; Giannitti, Federico; Parreño, Viviana; Colina, Rodney (Elsevier, 2020-12)Uruguay is a leading exporter of bovine meat and dairy products, and cattle production is one of the principal economic backbones in this country. A main clinical problem faced by livestock farmers is neonatal calf diarrhea ... -
Development of a platform process for the production and purification of single‐domain antibodies
Crowell, Laura E.; Goodwine, Chaz; Sosa Holt, Carla Solange; Rocha, Lucía Alejandra; Vega, Celina Guadalupe; Rodriguez-Aponte, Sergio A.; Dalvie, Neil C.; Tracey, Mary Kate; Puntel, Mariana; Wigdorovitz, Andres; Parreño, Gladys; Love, Kerry R.; Cramer, Steven M.; Love, J. Christopher (Wiley, 2021-09)Single-domain antibodies (sdAbs) offer the affinity and therapeutic value of conventional antibodies, with increased stability and solubility. Unlike conventional antibodies, however, sdAbs do not benefit from a platform ... -
Development of an IgY-Based treatment to control bovine Coronavirus diarrhea in dairy calves
Bok, Marina; Vega, Celina Guadalupe; Castells, Matias; Colina, Rodney; Wigdorovitz, Andres; Parreño, Gladys Viviana (MDPI, 2023-03)Bovine Coronavirus (BCoV) is a major pathogen associated with neonatal calf diarrhea. Standard practice dictates that to prevent BCoV diarrhea, dams should be immunized in the last stage of pregnancy to increase BCoV-specific ... -
Development of diagnostic tools for IBDV detection using plants as bioreactors
Gomez, Evangelina Raquel; Cassani, María Florencia; Lucero, Maria Soledad; Parreño, Viviana; Chimeno Zoth, Silvina Andrea; Berinstein, Analia (SpringerOpen, 2020-05)Infectious bursal disease virus (IBDV) is the etiological agent of an immunosuppressive and highly contagious disease that affects young birds, thus causing important economic losses in the poultry industry. Multimeric ... -
Development of nanobody-displayed whole-cell biosensors for the colorimetric detection of SARS-CoV‑2
He, Yawen; Xu, Zhiyuan; Kasputis, Tom; Zhao, Xue; Ibañez, Itati; Pavan, Florencia; Bok, Marina; Malito, Juan Pablo; Parreño, Gladys Viviana; Yuan, Lijuan; Wright, R. Clay; Chen, Juhong (American Chemical Society, 2023-08)The accurate and effective detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential to preventing the spread of infectious diseases and ensuring human health. Herein, a nanobody-displayed ... -
Development of recombinant VHH nanobodies as an alternative for clearance of equine arteritis virus in carrier stallions
Aduriz Guerrero, Matías; Carossino, Mariano; Go, Y.Y.; Vincke, Cécile; Balasuriya, Udeni B.R.; Muyldermans, S.; Wigdorovitz, Andres; Barrandeguy, Maria Edith; Parreño, Viviana (2016)In conclusion, a VHH library derived from llama B cells following immunization with EAV was generated. This novel strategy could allow the generation of EAV-specific neutralizing Nbs as a therapeutic approach to induce ... -
Discovery and molecular characterization of a group A rotavirus strain detected in an Argentinean vicuña (Vicugna vicugna)
Badaracco, Alejandra; Matthijnssens, Jelle; Romero, Sandra Raquel; Heylen, Elisabeth; Zeller, Mark; Garaicoechea, Lorena Laura; Van Ranst, Marc; Parreño, Gladys Viviana (Elsevier, 2013-01-25)The wild vicuña (Vicugna vicugna) is one of the four species of native South American camelids (SACs) in addition to the wild guanaco, and their domesticated counterparts, alpaca and llama, respectively. Serological data ... -
Dynamics of neutralizing antibodies against Bovine respiratory syncytial virus in a dairy herd from Santa Fe Province, Argentina = Dinámica de anticuerpos neutralizantes contra el virus respiratorio sincitial bovino en un rodeo lechero de la provincia de Santa Fe, Argentina
Ferella, Alejandra; Perez Aguirreburiald, Maria Sol; Sammarruco, Romina Ayelén; Parreño, Viviana; Dus Santos, Maria Jose; Mozgovoj, Marina Valeria (Elsevier, 2020-05)Bovine respiratory syncytial virus (BRSV) is one of the most relevant agents responsible for respiratory disease in cattle from both dairy and beef farms. BRSV is spread by horizontal contact causing a constant presence ... -
Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure
Pinheiro, Filipe Aguera; Decaris, Nathália; Parreño, Gladys Viviana; Brandão, Paulo Eduardo; Ayres, Henderson; Gomes, Viviani (BioMed Central, 2022-08)Background: Neonatal calf diarrhea (NCD) is the leading cause of calf morbidity and mortality in beef cattle. Cow’s vaccination in last stage of pregnancy is one of the most important measures to mitigate the risk of NCD ... -
Equine rotavirus a under the one health lens : potential impacts on public health
Carossino, Mariano; Vissani, Maria Aldana; Barrandeguy, Maria Edith; Balasuriya, Udeni B.R.; Parreño, Gladys Viviana (MDPI, 2024-01)Group A rotaviruses are a well-known cause of viral gastroenteritis in infants and children, as well as in many mammalian species and birds, affecting them at a young age. This group of viruses has a double-stranded, ...