Instituto de Virología
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FMD empty capsids combined with the immunostant particle adjuvant -ISPA or ISA206 induce protective immunity against foot and mouth disease virus
(Elsevier, 2021-05)Foot and Mouth Disease Virus (FMDV) causes economy losses and is controlled by vaccination in many countries. Vaccine formulations based on empty capsids or Virus-Like Particles (VLPs) have the advantage of avoiding the ... -
Preservation of protective capacity of hyperimmune anti-Stx2 bovine colostrum against enterohemorrhagic Escherichia coli O157:H7 pathogenicity after pasteurization and spray-drying processes
(Elsevier, 2021-05)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major etiologic agent that causes bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). Shiga toxin (Stx) is the main virulence factor of EHEC ... -
Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
(Elsevier, 2021-04)Porcine circovirus type 2 (PCV2) and protoparvovirus 1 (PPV) were detected as single infection (6/131) and (11/131) respectively, or co-infection (6/131) in fetuses and stillborn piglets from normal deliveries in a farm ... -
Towards inclusive funding practices for early career researchers
(2021-03)Securing research funding is a challenge faced by most scientists in academic institutions worldwide. Funding success rates for all career stages are low, but the burden falls most heavily on early career researchers (ECRs). ... -
Balance between retroviral latency and transcription : based on HIV model
(MDPI, 2021-01)The representative of the Lentivirus genus is the human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). To date, there is no cure for AIDS because of the existence ... -
Evaluation of a lyophilized CRISPR-Cas12 assay for a sensitive, specific, and rapid detection of SARS-CoV-2
(MDPI, 2021-03)We evaluated a lyophilized CRISPR-Cas12 assay for SARS-CoV-2 detection (Lyo-CRISPR SARS-CoV-2 kit) based on reverse transcription, isothermal amplification, and CRISPR-Cas12 reaction. From a total of 210 RNA samples extracted ... -
An improved DNA vaccine against bovine herpesvirus-1 using CD40L and a chemical adjuvant induces specific cytotoxicity in mici
(Mary Ann Liebert, 2021-03)Bovine herpesvirus-1 (BoHV-1) uses many mechanisms to elude the immune system; one of them is spreading intracellularly, even in the presence of specific antiviral antibodies. Cytotoxic T lymphocytes (CTLs) are necessary ... -
Expression-based analysis of genes related to single nucleotide polymorphism hits associated with bovine leukemia virus proviral load in Argentinean dairy cattle
(Elsevier, 2021-02)In dairy cattle infected with bovine leukemia virus (BLV), the proviral load (PVL) level is directly related to the viral transmission from infected animals to their healthy herdmates. Two contrasting phenotypic groups can ... -
A new cage-like particle adjuvant enhances protection of foot-and-mouth disease vaccine
(Frontiers Media, 2020-07)Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ... -
Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles
(Frontiers Media, 2020-09)Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). ... -
A plasmid encoding the extracellular domain of CD40 ligand and MontanideTM GEL01 as adjuvants enhance the immunogenicity and the protection induced by a DNA vaccine against BoHV-1
(Elsevier, 2021-02)DNA vaccines are capable of inducing humoral and cellular immunity, and are important to control bovine herpesvirus 1 (BoHV-1), an agent of the bovine respiratory disease complex. In previous work, a DNA plasmid that encodes ... -
Analysis of irradiated Argentinean fetal bovine serum for adventitious agents
(Sage Publications, 2020-11)Fetal bovine serum (FBS) used in cell culture may be contaminated with adventitious agents, which can affect the production of biologicals and the results of clinical laboratory tests. We carried out a retrospective study ... -
Desarrollo y evaluación de tecnología para la detección de proteínas no estructurales del Virus de la Fiebre Aftosa en formulaciones vacunales
(Universidad Nacional de San Martín, 2009)La fiebre aftosa (FA) es una enfermedad viral altamente contagiosa que afecta a todas las especies de pezuña hendida, salvajes y domésticas. Las especies domésticas principalmente afectadas son los bovinos, porcinos, ovinos ... -
Editorial: Emerging swine viruses
(Frontiers Media, 2020-03)Over the last 30 years, diseases caused by emerging swine viruses (ESV) have acquired great relevance, more than in other species. Diseases caused by porcine reproductive and respiratory syndrome virus (PRRSv), high ... -
In-vivo activity of IFN-λ and IFN-α against bovine-viral-diarrhea virus in a mouse model
(Frontiers Media, 2020-02)Bovine-viral-diarrhea virus (BVDV) can cause significant economic losses in livestock. The disease is controlled with vaccination and bovines are susceptible until vaccine immunity develops and may remain vulnerable if a ... -
MANα1-2MAN decorated liposomes enhance the immunogenicity induced by a DNA vaccine against BoHV-1
(Wiley, 2020-07)New technologies in the field of vaccinology arise as a necessity for the treatment and control of many diseases. Whole virus inactivated vaccines and modified live virus ones used against Bovine Herpesvirus‐1 (BoHV‐1) ... -
Efficacy of the spray-drying treatment to inactivate the bovine leukemia virus in bovine colostrum
(Elsevier, 2020-07)Previous studies have shown the presence of bovine leukemia virus (BLV) in colostrum and milk of naturally infected cows. The relationship between virus or provirus and specific antibodies in these secretions is particular ... -
Morir en soledad: la terrible situación de las personas que fallecen por COVID-19 y el dolor de sus familiares en un contexto de desborde del sistema de salud
(Sociedad Argentina de Medicina, 2020-09)La Organización Mundial de la Salud declaró la pandemia de covid-19 el 11 de marzo de 2020. El coronavirus pandémico afecta a todo el mundo desde que se identificó en diciembre de 2019 en Wuhan, China. La pandemia causó ... -
Dying alone due to COVID-19 : do the needs of the many outweigh the rights of the few—or the one?
(Frontiers Media, 2020-11)The COVID-19 pandemic, caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been striking the world since it was first identified in December 2019 in China. The World Health ... -
Bovine interferon lambda Is a potent antiviral against SARS-CoV-2 infection in vitro
(Frontiers Media, 2020-11)Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced ...