Instituto de Virología
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Incubadoras de empresas en INTA: capacidades y resultados (2008-2022)
(Ediciones INTA, 2022-10)En el INTA, como en la gran mayoría de las instituciones públicas de investigación y desarrollo (I+D), los proyectos biotecnológicos suelen obtener resultados a escala de laboratorio. Por lo general se enmarcan como tesis ... -
Cápsides virales como vacunas contra el virus de la Fiebre Aftosa. Selección, potenciación y estudio de la respuesta inmune inducida
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2022-06-08)La Fiebre Aftosa (FA) es una enfermedad infectocontagiosa aguda, causada por el Virus de la Fiebre Aftosa (VFA). La enfermedad afecta a bovinos, ovinos, cerdos y varias especies silvestres, se caracteriza por la aparición ... -
Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure
(BioMed Central, 2022-08)Background: Neonatal calf diarrhea (NCD) is the leading cause of calf morbidity and mortality in beef cattle. Cow’s vaccination in last stage of pregnancy is one of the most important measures to mitigate the risk of NCD ... -
Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle
(MDPI, 2022-08)Foot-and-mouth disease (FMD) remains one of the major threats to animal health worldwide. Its causative agent, the FMD virus (FMDV), affects cloven-hoofed animals, including farm animals and wildlife species, inflicting ... -
Development of a droplet digital PCR assay for quantification of the proviral load of bovine leukemia virus
(Sage Publications, 2022-05)Droplet digital PCR (ddPCR) is a highly sensitive tool developed for the detection and quantification of short-sequence variants—a tool that offers unparalleled precision enabling measurement of smaller-fold changes. We ... -
Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
(BioMed Central, 2022-06)Clostridioides difficile (C. difficile) is a gram-positive, spore-forming, anaerobic bacterium known to be the most common cause of hospital-acquired and antibiotic-associated diarrhea. C. difficile infection rates are on ... -
Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
(Elsevier, 2021-08)Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases ... -
Anthropogenic infection of domestic cats with SARS-CoV-2 alpha variant B.1.1.7 lineage in Buenos Aires
(Frontiers Media, 2022-03)SARS-CoV-2 reverse zoonosis, particularly to domestic animals, and the potential role of infected animals in perpetuating the spread of the virus is an issue of increasing concern. In this case report, we identified the ... -
Heat‑related massive chick mortality in an Imperial Cormorant Leucocarbo atriceps colony from Patagonia, Argentina
(Springer, 2022-02)Climate change has exacerbated the frequency and severity of heat waves, which on occasion lead to mass mortalities. Here, we report a massive mortality event in Imperial Cormorant Leucocarbo atriceps chicks that took place ... -
Whole-genome analysis of natural interspecific recombinant between bovine alphaherpesviruses 1 and 5
(Elsevier, 2022-02)Bovine alphaherpesviruses 1 and 5 (BoHV-1 and BoHV-5) are closely related viruses that co-circulate in South America and recombine in the field. The complete genomes of three natural gB gene recombinant viruses between ... -
Detection, risk factors and molecular diversity of norovirus GIII in cattle in Uruguay
(Elsevier, 2020-12)Uruguay is a leading exporter of bovine meat and dairy products, and cattle production is one of the principal economic backbones in this country. A main clinical problem faced by livestock farmers is neonatal calf diarrhea ... -
TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1
(Elsevier, 2022-01)The innate and acquired immune response induced by a commercial inactivated vaccine against Bovine Herpesvirus-1 (BoHV-1) and protection conferred against the virus were analyzed in cattle. Vaccination induced high levels ... -
Equine Coital Exanthema: new insights on the knowledge and leading perspectives for treatment and prevention
(MDPI, 2021-08)Equine coital exanthema (ECE) is a highly contagious, venereally-transmitted mucocutaneous disease, characterized by the formation of papules, vesicles, pustules and ulcers on the external genital organs of mares and ... -
Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus
(BMC, 2021-05)Background: Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the ... -
FMD empty capsids combined with the immunostant particle adjuvant -ISPA or ISA206 induce protective immunity against foot and mouth disease virus
(Elsevier, 2021-05)Foot and Mouth Disease Virus (FMDV) causes economy losses and is controlled by vaccination in many countries. Vaccine formulations based on empty capsids or Virus-Like Particles (VLPs) have the advantage of avoiding the ... -
Preservation of protective capacity of hyperimmune anti-Stx2 bovine colostrum against enterohemorrhagic Escherichia coli O157:H7 pathogenicity after pasteurization and spray-drying processes
(Elsevier, 2021-05)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major etiologic agent that causes bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). Shiga toxin (Stx) is the main virulence factor of EHEC ... -
Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
(Elsevier, 2021-04)Porcine circovirus type 2 (PCV2) and protoparvovirus 1 (PPV) were detected as single infection (6/131) and (11/131) respectively, or co-infection (6/131) in fetuses and stillborn piglets from normal deliveries in a farm ... -
Towards inclusive funding practices for early career researchers
(2021-03)Securing research funding is a challenge faced by most scientists in academic institutions worldwide. Funding success rates for all career stages are low, but the burden falls most heavily on early career researchers (ECRs). ... -
Balance between retroviral latency and transcription : based on HIV model
(MDPI, 2021-01)The representative of the Lentivirus genus is the human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). To date, there is no cure for AIDS because of the existence ... -
Evaluation of a lyophilized CRISPR-Cas12 assay for a sensitive, specific, and rapid detection of SARS-CoV-2
(MDPI, 2021-03)We evaluated a lyophilized CRISPR-Cas12 assay for SARS-CoV-2 detection (Lyo-CRISPR SARS-CoV-2 kit) based on reverse transcription, isothermal amplification, and CRISPR-Cas12 reaction. From a total of 210 RNA samples extracted ...