Instituto de Virología
Envíos recientes
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Equine coital exanthema : New approaches to minimise the negative impact on the equine industry
(Wiley, 2024-10)Equine coital exanthema (ECE), caused by Equid alphaherpesvirus 3 (EHV-3), is a highly contagious, venereally transmitted mucocutaneous disease, characterised by the formation of papules, vesicles, pustules and ulcers on ... -
Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina
(MDPI, 2024-10)Western equine encephalitis virus (WEEV) is a mosquito-borne arbovirus (genus Alphavirus, family Togaviridae) that has re-emerged in South America in late 2023, causing severe disease in both horses and humans after a ... -
The complete genome of equid herpesvirus‑1 (EHV‑1) feld isolates from Argentina reveals an interspecifc recombinant strain
(Springer, 2024-10)The Equid alphaherpesvirus type 1 (EHV-1) infection can have devastating economic consequences in the horse industry due to large-scale outbreaks of abortions, perinatal foal mortality, and myeloencephalopathy. The present ... -
Chronic NOD2 stimulation by MDP confers protection against parthanatos through M2b macrophage polarization in RAW264.7 cells
(Elsevier, 2024-09)Innate immune cells show enhanced responsiveness to secondary challenges after an initial non-related stimulation (Trained Innate Immunity, TII). Acute NOD2 activation by Muramyl-Dipeptide (MDP) promotes TII inducing the ... -
Detection and characterization of Deformed Wing Virus (DWV) in apiaries with stationary and migratory management in the province of Entre Ríos, Argentina
(Springer Nature, 2024-07)In Argentina, migratory activity in search of floral diversity has become a common approach to maximizing honey production. The Entre Ríos province possesses a floral diversity that allows beekeepers to perform migratory ... -
Secuencias parciales del gen NS1 de Parvovirus Equino-Hepatitis (EqPV-H) detectados en sueros equinos de Argentina [Conjunto de datos]
(Instituto Nacional de Tecnología Agropecuaria (INTA); Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 2024)El set de datos corresponde a 12 secuencias parciales del gen NS1 de Parvovirus Equino-Hepatitis (EqPV-H). Estas secuencias fueron detectadas en sueros equinos provenientes de caballos donantes y de sueros equinos comerciales ... -
First report of Equine Parvovirus-Hepatitis (EqPV-H) in Argentina
(Elsevier, 2024-07)The novel Equine Parvovirus-Hepatitis (EqPV-H) was first identified in the serum and liver of a horse that died of equine serum hepatitis, also known as Theiler's disease. Several reports in recent years strongly suggest ... -
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology
(Elsevier, 2024-09)Wastewater-based epidemiology (WBE) has gained prominence worldwide as a powerful tool in public health. This study aimed to monitor the circulation of Hepatitis E Virus (HEV) from wastewater samples collected during a ... -
Fasciola hepatica infection modifies IgG1 specific immune response to foot-and-mouth disease virus induced by vaccination
(Elsevier, 2024-01)Fasciola hepatica, a worldwide distributed helminth, has a robust immunoregulatory effect in the host, increasing the susceptibility to secondary infections. Foot and mouth disease (FMD) is a highly contagious acute vesicular ... -
SARS-CoV-2 specific nanobodies neutralize different variants of concern and reduce virus load in the brain of h-ACE2 transgenic mice
(MDPI, 2024-02)Since the beginning of the COVID-19 pandemic, there has been a significant need to develop antivirals and vaccines to combat the disease. In this work, we developed llama-derived nanobodies (Nbs) directed against the ... -
Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
(MDPI, 2024-06)Bovine alphaherpesvirus 1 (BoAHV-1) infection affects the production and reproductive performance of dairy and beef livestock, resulting in considerable economic losses. In addition to biosecurity measures, vaccination ... -
Detección de agentes virales presentes en apiarios destinados a la producción de material vivo y evaluación de estrategias para su control mediante ARN interferente
(Facultad de Agronomía, Universidad de Buenos Aires, 2023-11-02)En el sector apícola, Argentina se posiciona como uno de los principales actores a nivel global. La actividad local se destaca principalmente en la producción de miel a granel y otros productos obtenidos de la colmena ... -
Equine rotavirus a under the one health lens : potential impacts on public health
(MDPI, 2024-01)Group A rotaviruses are a well-known cause of viral gastroenteritis in infants and children, as well as in many mammalian species and birds, affecting them at a young age. This group of viruses has a double-stranded, ... -
Complete genome sequence of deformed wing virus and black queen cell virus isolated from honeybees (Apis mellifera) in Argentina
(American Society for Microbiology, 2024-03)We report the complete genome sequence of deformed wing virus and black queen cell virus isolated from Argentinean’s honeybees. These sequence data will be valuable for future research on the viral variants present in the ... -
A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations containing alum increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection in mice
(Frontiers Media, 2022-02)In this work, we evaluated recombinant receptor binding domain (RBD)-based vaccine formulation prototypes with potential for further clinical development. We assessed different formulations containing RBD plus alum, AddaS03, ... -
Longitudinal follow-up of the immunity to SARS-CoV-2 in health care workers in Argentina : persistence of humoral response and neutralizing capacity after Sputnik V vaccination
(American Society for Microbiology, 2023-06)SARS-CoV-2 vaccine protection has encountered waning of immune response and breakthrough infections. The hybrid immune response generated by the combination of vaccination and infection was shown to offer higher and broader ... -
Molecular characterization of group A rotavirus strains detected in alpacas (Vicugna pacos) from Peru
(Microbiology Society, 2021-04)The alpaca is a very important social and economic resource for the production of fibre and meat for Andean communities. Peru is the main producer of alpacas. Group A rotavirus (RVA) has been sporadically detected in ... -
Impact of genetic ancestry on the distribution of interferon-λ4 RS12979860 polymorphism in a global population of Buenos Aires, Argentina = Impacto de la ancestría genética en la distribución del polimorfismo de interferón-λ4 RS12979860 en una población global de Buenos Aires, Argentina
(Sociedad Argentina de Genética, 2022-12)Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have ... -
The MVA vector expressing the F protein of bovine respiratory syncytial virus is immunogenic in systemic and mucosal immunization routes = El vector viral MVA que expresa la proteína F del virus respiratorio sincicial bovino es inmunogénico al administrarse por vía sistémica y por mucosas
(Elsevier, 2023-12)Bovine respiratory syncytial virus (BRSV) affects both beef and dairy cattle, reaching morbidity and mortality rates of 60---80% and 20%, respectively. The aim of this study was to obtain a recombinant MVA expressing the ... -
A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity
(Nature Publishing Group, 2023-10)Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus ...