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Mhc-B haplotypes in “Campero-Inta” chicken synthetic line

Abstract
The major histocompatibility complex-B (MHC-B) in chickens is a cluster of genes located on chromosome 16. The chicken MHC-B is known to be highly associated with resistance to numerous diseases caused by viruses, bacteria, and parasitic pathogens. Since the level of resistance varies with MHC-B haplotypes, identification and classification of different haplotypes within lines is important for sustaining lines. The “Campero-INTA” chicken breed is a [ver mas...]
The major histocompatibility complex-B (MHC-B) in chickens is a cluster of genes located on chromosome 16. The chicken MHC-B is known to be highly associated with resistance to numerous diseases caused by viruses, bacteria, and parasitic pathogens. Since the level of resistance varies with MHC-B haplotypes, identification and classification of different haplotypes within lines is important for sustaining lines. The “Campero-INTA” chicken breed is a meat-type free-range poultry breed that was developed specifically for small producers in Argentina. Campero-INTA was started by selection in populations produced by crosses between a variety of established lines. MHC-B variation was examined in 65 samples obtained in 2002 using the VNTR marker LEI0258, a marker for MHC-B region. These samples plus and an additional 55 samples from 2018 were examined for variation using the MHC-B specific SNP panel that encompasses ∼230,000bp of the MHC-B region. Eleven MHC-B SNP haplotypes with 6 LEI0258 alleles were identified in the 120 samples representing the Campero-INTA AH (male) line. Seven haplotypes originate from the breeds originally used in the development of Campero-INTA AH line. Two appear to be recombinant haplotypes. The origin of the remaining 2 is not known, but may be associated with genes introduced from crosses with the Fayoumi breed conducted more recently to sustain the line. [Cerrar]
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Author
Iglesias, Gabriela M.;   Canet, Zulma Edith;   Cantaro, Horacio Luis;   Miquel, María Cristina;   Melo, Julián E.;   Miller, Marcia Madsen;   Berres, Mark E.;   Fulton, Janet E.;  
Fuente
Poultry science 98 (11) 1 : 5281-5286. (November 2019)
Date
2019-11
Editorial
Elsevier
ISSN
0032-5791
URI
http://hdl.handle.net/20.500.12123/7298
https://www.sciencedirect.com/science/article/pii/S0032579119457295
DOI
https://doi.org/10.3382/ps/pez431
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artículo
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Excepto donde se diga explicitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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