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Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge

Abstract
The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to prevent disease generalization after oronasal infection in animals passively transferred with 26-dpv serum but not with the 7-dpv serum. Conversely, [ver mas...]
The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to prevent disease generalization after oronasal infection in animals passively transferred with 26-dpv serum but not with the 7-dpv serum. Conversely, conventional FMD vaccination provided clinical protection at 7 dpv, promoting fast and robust antibody responses upon challenge and even though antibody titers were similar to those found in animals passively immunized with 7-dpv serum. These results demonstrate that presence of antigen-specific antibodies is critical to prevent the dissemination of the virus within the animal. Conventional FMD vaccination additionally promoted the deployment of rapid, high titer and isotype-switched antibody responses at systemic and mucosal levels after infection, thus conferring protection even in the presence of low pre-challenge antibody titers. [Cerrar]
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Author
Barrionuevo, Florencia Mariel;   Di Giacomo, Sebastián;   Bucafusco, Danilo;   Ayude, Andrea Fabiana;   Schammas, Juan Manuel;   Miraglia, María Cruz;   Capozzo, Alejandra Victoria;   Borca, Manuel Victor;   Perez Filgueira, Daniel Mariano;  
Fuente
Virology 518 : 143-151. (May 2018)
Date
2018-05
ISSN
0042-6822
URI
https://www.sciencedirect.com/science/article/pii/S0042682218300552
http://hdl.handle.net/20.500.12123/2540
DOI
https://doi.org/10.1016/j.virol.2018.02.012
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pdf
Tipo de documento
artículo
Palabras Claves
Ganado Bovino; Cattle; Enfermedades de los Animales; Animal Diseases; Fiebre Aftosa; Foot and Mouth Disease; Anticuerpos; Antibodies; Inmunidad Pasiva; Passive Immunity;
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Excepto donde se diga explicitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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