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Single nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattle

Abstract
The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in [ver mas...]
The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs. [Cerrar]
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Author
Nani, Juan Pablo;   Raschia, Maria Agustina;   Carignano, Hugo;   Poli, Mario Andres;   Calvinho, Luis Fernando;   Amadio, Ariel;  
Fuente
Journal of Applied Genetics 56 (4) : 505–513 (November 2015)
Date
2015-11
ISSN
1234-1983
2190-3883
URI
https://link.springer.com/article/10.1007%2Fs13353-015-0278-5
http://hdl.handle.net/20.500.12123/2823
DOI
https://doi.org/10.1007/s13353-015-0278-5
Formato
pdf
Tipo de documento
artículo
Palabras Claves
Ganado de Leche; Dairy Cattle; Control de Enfermedades; Disease Control; Enfermedades de los Animales; Animal Diseases; Mastítis Bovina; Bovine Mastitis; Genes; Células Somáticas; Somatic Cells; Argentina;
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Excepto donde se diga explicitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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