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resumen

Resumen
The representative of the Lentivirus genus is the human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). To date, there is no cure for AIDS because of the existence of the HIV-1 reservoir. HIV-1 infection can persist for decades despite effective antiretroviral therapy (ART), due to the persistence of infectious latent viruses in long-lived resting memory CD4+ T cells, macrophages, monocytes, [ver mas...]
dc.contributor.authorPluta, Aneta
dc.contributor.authorJaworski, Juan Pablo
dc.contributor.authorCortés-Rubio, César N.
dc.date.accessioned2021-04-21T14:25:05Z
dc.date.available2021-04-21T14:25:05Z
dc.date.issued2021-01
dc.identifier.issn2076-0817
dc.identifier.otherhttps://doi.org/10.3390/pathogens10010016
dc.identifier.urihttp://hdl.handle.net/20.500.12123/9143
dc.identifier.urihttps://www.mdpi.com/2076-0817/10/1/16
dc.description.abstractThe representative of the Lentivirus genus is the human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). To date, there is no cure for AIDS because of the existence of the HIV-1 reservoir. HIV-1 infection can persist for decades despite effective antiretroviral therapy (ART), due to the persistence of infectious latent viruses in long-lived resting memory CD4+ T cells, macrophages, monocytes, microglial cells, and other cell types. However, the biology of HIV-1 latency remains incompletely understood. Retroviral long terminal repeat region (LTR) plays an indispensable role in controlling viral gene expression. Regulation of the transcription initiation plays a crucial role in establishing and maintaining a retrovirus latency. Whether and how retroviruses establish latency and reactivate remains unclear. In this article, we describe what is known about the regulation of LTR-driven transcription in HIV-1, that is, the cis-elements present in the LTR, the role of LTR transcription factor binding sites in LTR-driven transcription, the role of HIV-1-encoded transactivator protein, hormonal effects on virus transcription, impact of LTR variability on transcription, and epigenetic control of retrovirus LTR. Finally, we focus on a novel clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR/dCas9)-based strategy for HIV-1 reservoir purging.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherMDPIes_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourcePathogens 10 (1) : 16 (Enero 2021)es_AR
dc.subjectRetroviridaees_AR
dc.subjectHuman Immunodeficiency Viruseng
dc.subjectVirus de la Inmunodeficiencia Humanaes_AR
dc.subjectHIV Infectionseng
dc.subjectInfección por VIHes_AR
dc.subjectLatent Infectionseng
dc.subjectInfecciones Latenteses_AR
dc.subjectCRISPReng
dc.subjectRepeticiones Palindrómicas Cortas Agrupadas y Regularmente Interespaciadases_AR
dc.subjectTranscriptioneng
dc.subjectTranscripciónes_AR
dc.subjectLentiviruses_AR
dc.titleBalance between retroviral latency and transcription : based on HIV modeles_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.origenInstituto de Virologíaes_AR
dc.description.filFil: Pluta, Aneta. National Veterinary Research Institute. Department of Biochemistry; Poloniaes_AR
dc.description.filFil: Jaworski, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentinaes_AR
dc.description.filFil: Jaworski, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentinaes_AR
dc.description.filFil: Cortés-Rubio, César N. National Institute of Respiratory Diseases. Centre for Research in Infectious Diseases; Méxicoes_AR
dc.subtypecientifico


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