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Abstract
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). Although inactivated vaccines have been effective in controlling the disease, they have some disadvantages. Because of these disadvantages, investigations are being made to produce vaccines in low containment facilities. The use of [ver mas...]
dc.contributor.authorQuattrocchi, Valeria
dc.contributor.authorBidart, Juan Esteban
dc.contributor.authorMignaqui, Ana Clara
dc.contributor.authorRuiz, Vanesa
dc.contributor.authorFerella, Alejandra
dc.contributor.authorLangellotti, Cecilia Ana
dc.contributor.authorGammella, Mariela
dc.contributor.authorFerraris, Sergio
dc.contributor.authorCarrillo, Jorge Ernesto
dc.contributor.authorWigdorovitz, Andres
dc.contributor.authorDurocher, Yves
dc.contributor.authorCardillo, Sabrina Beatriz
dc.contributor.authorCharleston, Bryan
dc.contributor.authorZamorano, Patricia Ines
dc.date.accessioned2021-02-19T11:00:30Z
dc.date.available2021-02-19T11:00:30Z
dc.date.issued2020-09
dc.identifier.issn2297-1769
dc.identifier.otherhttps://doi.org/10.3389/fvets.2020.00594
dc.identifier.urihttp://hdl.handle.net/20.500.12123/8689
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fvets.2020.00594/full
dc.description.abstractFoot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). Although inactivated vaccines have been effective in controlling the disease, they have some disadvantages. Because of these disadvantages, investigations are being made to produce vaccines in low containment facilities. The use of recombinant empty capsids (also referred as Virus Like Particles, VLPs) has been reported to be a promising candidate as a subunit vaccine because it avoids the use of virus in the vaccine production and conserves the conformational epitopes of the virus. Mignaqui and collaborators have produced recombinant FMDV empty capsids from serotype A/ARG/2001 using a scalable technology in mammalian cells that elicited a protective immunity against viral challenge in a mouse model. However, further evaluation of the immune response elicited by these VLPs in cattle is required. In the present work we compare the effect that VLPs or inactivated FMDV has on bovine dendritic cells and the humoral response elicited in cattle after a single vaccination.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherFrontiers Mediaes_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.sourceFrontiers in Veterinary Science 7 : 594 (Septiembre 2020)es_AR
dc.subjectAphthoviruseng
dc.subjectVirus Fiebre Aftosaes_AR
dc.subjectFoot and Mouth Diseaseeng
dc.subjectFiebre Aftosaes_AR
dc.subjectBovinaeeng
dc.subjectBovinaes_AR
dc.subjectAntibodieseng
dc.subjectAnticuerposes_AR
dc.subjectViruseseng
dc.subjectViruses_AR
dc.titleBovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particleses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Virologíaes_AR
dc.description.filFil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Bidart, Juan Esteban. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Mignaqui, Ana Clara. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentinaes_AR
dc.description.filFil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Ferella, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Langellotti, Cecilia Ana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Gammella, Mariela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFerraris, Sergio. Universidad Maimónides. Centro de Investigación y Desarrollo en Medicina Experimental; Argentinaes_AR
dc.description.filFil: Carrillo, Jorge Ernesto. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro de Investigación de Agroindustria; Argentina.es_AR
dc.description.filFil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Durocher, Yves. Human Health Therapeutics Research Center, National Research Council Canada; Canadáes_AR
dc.description.filFil: Cardillo, Sabrina Beatriz. Biogénesis-Bagó; Argentinaes_AR
dc.description.filFil: Charleston, Bryan. Pirbright Institute; Reino Unidoes_AR
dc.description.filFil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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