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Background: The emergence of azole resistance in non‐fumigatus Aspergillus strains is on the raise.
Objectives: To study the susceptibility profiles and the molecular mechanisms of azole resistance of environmental and clinical strains of Aspergillus flavus from Argentina.
Methods: Thirty‐five A flavus isolates (18 from soybean seeds and chickpea seeds and 17 from the clinic) were analysed for amphotericin B and azole resistance using the standard
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dc.contributor.author | Hermida‐Alava, Katherine | |
dc.contributor.author | Brito Devoto, Tomás | |
dc.contributor.author | Sautua, Francisco José | |
dc.contributor.author | Gordó, Manuela | |
dc.contributor.author | Scandiani, María Mercedes | |
dc.contributor.author | Formento, Angela Norma | |
dc.contributor.author | Luque, Alicia | |
dc.contributor.author | Carmona, Marcelo Anibal | |
dc.contributor.author | Cuestas, María L. | |
dc.date | info:eu-repo/date/embargoEnd/2021-10-18 | |
dc.date.accessioned | 2020-10-16T16:14:27Z | |
dc.date.available | 2020-10-16T16:14:27Z | |
dc.date.issued | 2020-10 | |
dc.identifier.issn | 0933-7407 | |
dc.identifier.issn | 1439-0507 | |
dc.identifier.other | https://doi.org/10.1111/myc.13193 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/8069 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/myc.13193 | |
dc.description.abstract | Background: The emergence of azole resistance in non‐fumigatus Aspergillus strains is on the raise. Objectives: To study the susceptibility profiles and the molecular mechanisms of azole resistance of environmental and clinical strains of Aspergillus flavus from Argentina. Methods: Thirty‐five A flavus isolates (18 from soybean seeds and chickpea seeds and 17 from the clinic) were analysed for amphotericin B and azole resistance using the standard microbroth dilution method according to CLSI M38‐A2 guidelines. Sequencing analysis of the cyp51 genes was conducted in those isolates displaying high MICs values to itraconazole, voriconazole and/or posaconazole. Results: Among the environmental isolates, 33.3% of them showed high MIC values for at least one triazole whereas 23.5% of the clinical isolates displayed high MIC values for amphotericin B. Point mutations in the Cyp51C gene were recorded in most environmental isolates with non‐wild‐type MIC values. Conclusions: Susceptibility differences among environmental A flavus isolates might suggest the possibility of native resistance to certain triazole antifungals used in the clinic. To the best of our knowledge, this is the first report of antifungal screening of environmental strains of A flavus in soybean seeds and chickpea seeds from Argentina that showed increased resistance to voriconazole and itraconazole in comparison to clinical strains. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Wiley | es_AR |
dc.rights | info:eu-repo/semantics/embargoedAccess | es_AR |
dc.source | Mycoses (First published: 01 October 2020) | es_AR |
dc.subject | Aspergillus flavus | es_AR |
dc.subject | Marcadores Genéticos | es_AR |
dc.subject | Genetic Markers | eng |
dc.subject | Identificación | es_AR |
dc.subject | Identification | eng |
dc.subject | Azoles | es_AR |
dc.subject | Argentina | es_AR |
dc.subject.other | Marcadores Moleculares | es_AR |
dc.subject.other | Triazoles | es_AR |
dc.title | Antifungal susceptibility profile and molecular identification of Cyp51C mutations in clinical and environmental isolates of Aspergillus flavus from Argentina | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/acceptedVersion | es_AR |
dc.description.origen | EEA Paraná | es_AR |
dc.description.fil | Fil: Hermida‐Alava, Katherine. Universidad de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina | es_AR |
dc.description.fil | Fil: Brito Devoto, Tomás. Universidad de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina | es_AR |
dc.description.fil | Fil: Sautua, Francisco José. Universidad de Buenos Aires. Facultad de Agronomía. Cátedra de Fitopatología; Argentina | es_AR |
dc.description.fil | Fil: Gordó, Manuela. Laboratorio Agrícola Río Parana; Argentina | es_AR |
dc.description.fil | Fil: Scandiani, Mercedes M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Referencia de Micología (CEREMIC); Argentina | es_AR |
dc.description.fil | Fil: Formento, Angela Norma. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Paraná; Argentina | es_AR |
dc.description.fil | Fil: Luque, Alicia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Referencia de Micología (CEREMIC); Argentina | es_AR |
dc.description.fil | Fil: Carmona, Marcelo Anibal. Universidad de Buenos Aires. Facultad de Agronomía. Cátedra de Fitopatología; Argentina | es_AR |
dc.description.fil | Fil: Cuestas, María L. Universidad de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina | es_AR |
dc.subtype | cientifico |
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