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resumen

Resumen
Equid alphaherpesvirus 3 (EHV-3) is the etiological agent of equine coital exanthema (ECE). Since no vaccines or antiviral therapies are available, prevention consists of clinical examination of mares and stallions before mating or semen collection and resting from breeding activities when lesions are present. However, this methodology does not identify subclinically infected animals. Ganciclovir is the most potent compound known to reduce EHV-3 [ver mas...]
dc.contributor.authorVissani, Maria Aldana
dc.contributor.authorOlguin Perglione, Cecilia
dc.contributor.authorZabal, Osvaldo Alfredo
dc.contributor.authorAlvarez, Gustavo
dc.contributor.authorThiry, Etienne
dc.contributor.authorBarrandeguy, Maria Edith
dc.contributor.authorParreño, Viviana
dc.dateinfo:eu-repo/date/embargoEnd/2021-08-02
dc.date.accessioned2020-07-31T17:29:13Z
dc.date.available2020-07-31T17:29:13Z
dc.date.issued2020-07
dc.identifier.issn0737-0806
dc.identifier.otherhttps://doi.org/10.1016/j.jevs.2020.103199
dc.identifier.urihttp://hdl.handle.net/20.500.12123/7653
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0737080620302902
dc.description.abstractEquid alphaherpesvirus 3 (EHV-3) is the etiological agent of equine coital exanthema (ECE). Since no vaccines or antiviral therapies are available, prevention consists of clinical examination of mares and stallions before mating or semen collection and resting from breeding activities when lesions are present. However, this methodology does not identify subclinically infected animals. Ganciclovir is the most potent compound known to reduce EHV-3 replication. This study aimed to evaluate the efficacy of topical ganciclovir application to reduce EHV-3 replication in experimentally infected mares. A pilot study, following a double-blind completely randomized design, was carried out. Twenty mares were randomly divided into five groups (three treated with ganciclovir with different regimen of doses, one treated with placebo and one non-treated). Mares were experimentally infected with EHV-3 on day 0. Rectal temperature, clinical signs, and lesions were recorded. Daily perineal and vaginal swabs were evaluated by qPCR for virus detection. The antibody response was assessed by a virus neutralisation test in serum samples collected weekly. Mares experimentally infected with EHV-3 and treated with ganciclovir twice a day for 13 days showed reduced levels and duration of viral excretion and less severe lesions. The viral excretion period was reduced from 18 to nine days compared with the untreated groups. We concluded that ganciclovir had an antiviral effect on EHV-3 replication when topically administered in mares showing clinical signs of ECE. Further trials should be performed to optimize the dose of the antiviral for a definitive formulation.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.rightsinfo:eu-repo/semantics/embargoedAccesses_AR
dc.sourceJournal of Equine Veterinary Science : 103199 (Available online 24 July 2020)es_AR
dc.subjectEnfermedades de los Animaleses_AR
dc.subjectAnimal Diseaseseng
dc.subjectCaballoses_AR
dc.subjectHorseseng
dc.subjectYeguaes_AR
dc.subjectMareseng
dc.subjectControl de Enfermedadeses_AR
dc.subjectDiseases Controleng
dc.subjectExantema Coitales_AR
dc.subjectCoital Exanthemaeng
dc.subject.otherEquine Coital Exanthemaeng
dc.subject.otherGanciclovires_AR
dc.titleTopical ganciclovir reduces viral excretion in mares with equine coital exanthemaes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/acceptedVersiones_AR
dc.description.origenInstituto de Virologíaes_AR
dc.description.filFil: Vissani, Aldana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología: Argentina. Universidad del Salvador. Escuela de Veterinaria. Cátedra de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Olguin Perglione, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentinaes_AR
dc.description.filFil: Zabal, Osvaldo Alfredo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología: Argentina. Universidad del Salvador. Escuela de Veterinaria. Cátedra de Enfermedades Infecciosas; Argentinaes_AR
dc.description.filFil: Alvarez, Gustavo. Argentina. Ejército. Dirección de Remonta y Veterinaria; Argentinaes_AR
dc.description.filFil: Thiry, Etienne. University of Liege. Faculty of Veterinary Medicine. FARAH Center. Department of Infectious and Parasitic Diseases. Veterinary Virology and Animal Viral Diseases; Bélgicaes_AR
dc.description.filFil: Barrandeguy, Maria Edith. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Universidad del Salvador. Escuela de Veterinaria. Cátedra de Enfermedades Infecciosas; Argentinaes_AR
dc.description.filFil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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