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Abstract
Bovine coronavirus (BCoV) is a recognized cause of severe neonatal calf diarrhea, with a negative impact on animal welfare, leading to economic losses to the livestock industry. Cattle production is one of the most important economic sectors in Uruguay. The aim of this study was to determine the frequency of BCoV infections and their genetic diversity in Uruguayan calves and to describe the evolutionary history of the virus in South America. The overall [ver mas...]
dc.contributor.authorCastells, Matias
dc.contributor.authorGiannitti, Federico
dc.contributor.authorCaffarena, Rubén Darío
dc.contributor.authorCasaux, María Laura
dc.contributor.authorSchild, Carlos
dc.contributor.authorCastells, Daniel
dc.contributor.authorRiet‑Correa, Franklin
dc.contributor.authorVictoria, Matias
dc.contributor.authorParreño, Gladys
dc.contributor.authorColina, Rodney
dc.date.accessioned2019-12-12T18:10:06Z
dc.date.available2019-12-12T18:10:06Z
dc.date.issued2019-11
dc.identifier.issn0304-8608
dc.identifier.issn1432-8798
dc.identifier.otherhttps://doi.org/10.1007/s00705-019-04384-w
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00705-019-04384-w
dc.identifier.urihttp://hdl.handle.net/20.500.12123/6501
dc.description.abstractBovine coronavirus (BCoV) is a recognized cause of severe neonatal calf diarrhea, with a negative impact on animal welfare, leading to economic losses to the livestock industry. Cattle production is one of the most important economic sectors in Uruguay. The aim of this study was to determine the frequency of BCoV infections and their genetic diversity in Uruguayan calves and to describe the evolutionary history of the virus in South America. The overall detection rate of BCoV in Uruguay was 7.8% (64/824): 7.7% (60/782) in dairy cattle and 9.5% (4/42) in beef cattle. The detection rate of BCoV in samples from deceased and live calves was 10.0% (6/60) and 7.6% (58/763), respectively. Interestingly, there was a lower frequency of BCoV detection in calves born to vaccinated dams (3.3%, 8/240) than in calves born to unvaccinated dams (12.2%, 32/263) (OR: 4.02, 95%CI: 1.81–8.90; p = 0.00026). The frequency of BCoV detection was higher in colder months (11.8%, 44/373) than in warmer months (1.5%, 3/206) (OR: 9.05, 95%CI: 2.77–29.53, p = 0.000013). Uruguayan strains grouped together in two different lineages: one with Argentinean strains and the other with Brazilian strains. Both BCoV lineages were estimated to have entered Uruguay in 2013: one of them from Brazil (95%HPD interval: 2011–2014) and the other from Argentina (95%HPD interval: 2010–2014). The lineages differed by four amino acid changes, and both were divergent from the Mebus reference strain. Surveillance should be maintained to detect possible emerging strains that can clearly diverge at the antigenic level from vaccine strains.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherSpringeres_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceArchives of Virology 164 (11): 2715–2724 (November 2019)es_AR
dc.subjectCoronaviruses_AR
dc.subjectGenetic Diversityeng
dc.subjectUruguayes_AR
dc.subjectEnfermedades de los Animales
dc.subjectAnimal Diseaseseng
dc.subjectGanado Bovino
dc.subjectCattleeng
dc.subjectDiversidad Genética
dc.titleBovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countrieses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Virologíaes_AR
dc.description.filFil: Giannitti, Federico. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.es_AR
dc.description.filFil: Caffarena, Rubén Darío. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal. Universidad de la República. Facultad de Veterinaria; Uruguay.es_AR
dc.description.filFil: Casaux, María Laura. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.es_AR
dc.description.filFil: Schild, Carlos. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.es_AR
dc.description.filFil: Castells, Daniel. Secretariado Uruguayo de la Lana. Centro de Investigación y Experimentación Dr. Alejandro Gallinal; Uruguay.es_AR
dc.description.filFil: Riet‑Correa, Franklin. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.es_AR
dc.description.filFil: Victoria, Matías. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.es_AR
dc.description.filFil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Argentina.es_AR
dc.description.filFil: Colina, Rodney. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.es_AR
dc.description.filFil: Castells_Matías. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.es_AR
dc.subtypecientifico


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