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Abstract
Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to [ver mas...]
dc.contributor.authorBarez, Pierre-Yves
dc.contributor.authorDe Brogniez, Alix
dc.contributor.authorCarpentier, Alexandre
dc.contributor.authorGazon, Hélène
dc.contributor.authorGillet, Nicolas
dc.contributor.authorGutierrez, Gerónimo
dc.contributor.authorHamaidia, Malik
dc.contributor.authorJacques, Jean-Rock
dc.contributor.authorPerike, Srikanth
dc.contributor.authorSriramareddy, Sathya Neelature
dc.contributor.authorRenotte, Nathalie
dc.contributor.authorStaumont, Bernard
dc.contributor.authorReichert, Michal
dc.contributor.authorTrono, Karina Gabriela
dc.contributor.authorWillems, Luc
dc.date.accessioned2019-06-13T12:09:52Z
dc.date.available2019-06-13T12:09:52Z
dc.date.issued2015-11
dc.identifier.issn1999-4915
dc.identifier.otherhttps://doi.org/10.3390/v7112929
dc.identifier.urihttps://www.mdpi.com/1999-4915/7/11/2929
dc.identifier.urihttp://hdl.handle.net/20.500.12123/5307
dc.description.abstractDifferent animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherMDPIes_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.sourceViruses 7 (11) : 6080-6088 (November 2015)es_AR
dc.subjectEnfermedades de los Animaleses_AR
dc.subjectAnimal Diseaseseng
dc.subjectVirus Leucemia Bovinaes_AR
dc.subjectBovine Leukaemia Viruseng
dc.subjectRespuesta Inmunológicaes_AR
dc.subjectImmune Responseeng
dc.subjectGanado Bovinoes_AR
dc.subjectCattleeng
dc.subjectVacunaes_AR
dc.subjectVaccineseng
dc.titleRecent advances in BLV researches_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Virologíaes_AR
dc.description.filFil: Barez, Pierre-Yves. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: de Brogniez, Alix. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Carpentier, Alexandre. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Gillet, Nicolas. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentinaes_AR
dc.description.filFil: Hamaidia, Malik. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Perike, Srikanth. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Sriramareddy, Sathya Neelature. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Renotte, Nathalie. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Staumont, Bernard. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.description.filFil: Reichert, Michal. National Veterinary Research Institute; Poloniaes_AR
dc.description.filFil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentinaes_AR
dc.description.filFil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgicaes_AR
dc.subtypecientifico


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