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Abstract
Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). Although inactivated virus vaccines have proved to be effective in FMD control, they have a number of disadvantages, including the need for high bio-containment production facilities and the lack of induction of immunological memory. [ver mas...]
dc.contributor.authorMignaqui, Ana Clara
dc.contributor.authorRuiz, Vanesa
dc.contributor.authorDurocher, Yves
dc.contributor.authorWigdorovitz, Andres
dc.date.accessioned2019-05-20T11:02:30Z
dc.date.available2019-05-20T11:02:30Z
dc.date.issued2019-05
dc.identifier.issn1549-7801
dc.identifier.otherhttps://doi.org/10.1080/07388551.2018.1554619
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/07388551.2018.1554619?journalCode=ibty20
dc.identifier.urihttp://hdl.handle.net/20.500.12123/5149
dc.description.abstractFoot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). Although inactivated virus vaccines have proved to be effective in FMD control, they have a number of disadvantages, including the need for high bio-containment production facilities and the lack of induction of immunological memory. Novel FMD vaccines based on the use of recombinant empty capsids have shown promising results. These recombinant empty capsids are attractive candidates because they avoid the use of virus in the production facilities but conserve its complete repertoire of conformational epitopes. However, many of these recombinant empty capsids require time-consuming procedures that are difficult to scale up. Achieving production of a novel and efficient FMD vaccine requires not only immunogenic antigens, but also industrially relevant processes. This review intends to summarize and compare the different strategies already published for the production of FMDV recombinant empty capsids, focusing on large-scale production.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherTaylor & Francises_AR
dc.relationinfo:eu-repograntAgreement/INTA/PNSA/1115052/AR./Epidemiología y desarrollo de estrategias para la prevención y control de enfermedades que afectan la salud pública, enfermedades exóticas y limitantes del comercio internacional.es_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceCritical Reviews in Biotechnology 39 (3) : 306-320 (Mayo 2019)es_AR
dc.subjectAphthoviruseng
dc.subjectVirus Fiebre Aftosaes_AR
dc.subjectVaccineseng
dc.subjectVacunaes_AR
dc.subjectViruseseng
dc.subjectViruses_AR
dc.titleAdvances in novel vaccines for foot and mouth disease: focus on recombinant empty capsidses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Virologíaes_AR
dc.description.filFil: Mignaqui, Ana Clara. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Durocher, Yves. National Research Council Canada. Human Health Therapeutics Research Center; Canadáes_AR
dc.description.filFil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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