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Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. This pathology is caused by foot-and-mouth disease virus (FMDV). Over time, the development of vaccines to prevent the spread of this illness became essential. Vaccines currently used contain the inactivated form of the virus. However, vaccination generates an immune response different to that induced by the infection. We investigated whether these differences are
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dc.contributor.author | Langellotti, Cecilia Ana | |
dc.contributor.author | Cesar, Gonzalo | |
dc.contributor.author | Soria, Ivana | |
dc.contributor.author | Quattrocchi, Valeria | |
dc.contributor.author | Jancic, Carolina Cristina | |
dc.contributor.author | Zamorano, Patricia Ines | |
dc.contributor.author | Vermeulen, Elba Monica | |
dc.date.accessioned | 2019-03-01T17:54:39Z | |
dc.date.available | 2019-03-01T17:54:39Z | |
dc.date.issued | 2015-09 | |
dc.identifier.issn | 0264-410X | |
dc.identifier.other | https://doi.org/10.1016/j.vaccine.2015.07.038 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/4535 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0264410X15009858?via%3Dihub | |
dc.description.abstract | Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. This pathology is caused by foot-and-mouth disease virus (FMDV). Over time, the development of vaccines to prevent the spread of this illness became essential. Vaccines currently used contain the inactivated form of the virus. However, vaccination generates an immune response different to that induced by the infection. We investigated whether these differences are related to intracellular mechanisms on dendritic cells (DCs). As a result, we demonstrated that the internalization of infective virus triggered the phosphorylation of ERK1/2, which was involved in the activation of caspase-9, the intrinsic pathway of apoptosis and the delivery of viral peptides on MHC class I molecules. While, inactivated virus (iFMDV) did not affect this pathway or any function mediated by its activation. As described, infectious virus in DCs was also associated to autophagy LC3 protein and was associated to lysosomal protein Lamp-2; contrary to observe for the iFMDV. Strikingly, the processing of viral antigens to accommodate in class I molecules does not appear to involve the proteasome. Finally, this increased presentation promotes a specific cytotoxic response against infectious virus. | eng |
dc.format | application/pdf | eng |
dc.language.iso | eng | |
dc.publisher | Elsevier | eng |
dc.rights | info:eu-repo/semantics/restrictedAccess | eng |
dc.source | Vaccine 33 (38) : 4945-4953. (11 September 2015) | eng |
dc.subject | Aphthovirus | eng |
dc.subject | Virus Fiebre Aftosa | es_AR |
dc.subject | Fosforilación | es_AR |
dc.subject | Phosphorylation | eng |
dc.subject | Cytotoxicity | eng |
dc.subject | Citotoxicidad | es_AR |
dc.subject.other | Foot and Mouth Disease Virus | eng |
dc.subject.other | Caspase-9 | eng |
dc.subject.other | ERK1/2 MAPK | es_AR |
dc.subject.other | Inactive Viral Particles | eng |
dc.subject.other | Células Dendríticas | es_AR |
dc.subject.other | ||
dc.title | Foot-and-mouth disease virus infection of dendritic cells triggers phosphorylation of ERK1/2 inducing class I presentation and apoptosis | eng |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | eng |
dc.description.origen | Instituto de Virología | es_AR |
dc.description.fil | Fil: Langellotti, Cecilia Ana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Cesar, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | es_AR |
dc.description.fil | Fil: Soria, Ivana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Quattrocchi, Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina | es_AR |
dc.description.fil | Fil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | es_AR |
dc.description.fil | Fil: Zamorano, Patricia Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Vermeulen, Elba Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | es_AR |
dc.subtype | cientifico |
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