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An efficient vaccine against bovine leukemia virus
(BioMed Central, 2015)Previous attempts to produce a vaccine against BLV faced problems of efficacy (i.e. only a fraction of animals were protected), persistence (i.e. rapid decrease of immune protection), cost (e.g. production of purified ... -
Bovine leukemia virus encoded blv-miR-b4-3p microRNA is associated with reduced expression of anti-oncogenic gene in vivo
(PLOS, 2023-02)Bovine leukemia virus (BLV) is a retrovirus that causes malignant B-cell lymphoma in up to ten-percent of infected cattle. To date, the mechanisms of BLV linked to malignant transformation remain elusive. Although BLV-encoded ... -
Bovine leukemia virus infection in neonatal calves. Risk factors and control measures
(Frontiers Media, 2018-10)Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL). Although efficient eradication programs have been successfully implemented in most European countries and Oceania, BLV infection rates ... -
Bovine leukemia virus small noncoding RNAs are functional elements that regulate replication and contribute to oncogenesis in vivo
(2016-04)Retroviruses are not expected to encode miRNAs because of the potential problem of self-cleavage of their genomic RNAs. This assumption has recently been challenged by experiments showing that bovine leukemia virus (BLV) ... -
Characterization of colostrum from dams of BLV endemic dairy herds
(Elsevier, 2015-06)Bovine Leukemia Virus (BLV) is endemic in Argentina, where the individual prevalence is higher than 80% in dairy farms. The aim of this work was to find preliminary evidence to know if the high level of infection of the ... -
Detection of bovine leukemia virus RNA in blood samples of naturally infected dairy cattle
(MDPI, 2019-09)The viral expression in vivo, in bovine leukemia virus (BLV)-infected cattle, is considered to be restricted to extremely low levels, and the mitosis of infected B lymphocytes is regarded as the main mode of virus persistence ... -
Development of a droplet digital PCR assay for quantification of the proviral load of bovine leukemia virus
(Sage Publications, 2022-05)Droplet digital PCR (ddPCR) is a highly sensitive tool developed for the detection and quantification of short-sequence variants—a tool that offers unparalleled precision enabling measurement of smaller-fold changes. We ... -
Dynamics of perinatal bovine leukemia virus infection
(BioMed Central, 2014)Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important ... -
Efficacy of the spray-drying treatment to inactivate the bovine leukemia virus in bovine colostrum
(Elsevier, 2020-07)Previous studies have shown the presence of bovine leukemia virus (BLV) in colostrum and milk of naturally infected cows. The relationship between virus or provirus and specific antibodies in these secretions is particular ... -
Evaluation of serological response to foot-and-mouth disease vaccination in BLV infected cows
(2016)Bovine Leukemia Virus (BLV) produces disorders on the immune system in naturally infected animals, which may counteract the development of immunity after vaccination. The aim of this study was to investigate whether healthy ... -
Evaluation of total white blood cell count as a marker for proviral load of bovine leukemia virus in dairy cattle from herds with a high seroprevalence of antibodies against bovine leukemia virus
(2013-05)Objective—To determine the reference interval for WBC counts in Holstein dairy cows from herds with high seroprevalence for anti–bovine leukemia virus (BLV) antibodies, analyze the correlation of total WBC counts and blood ... -
Experimental infection of sheep with bovine leukemia virus (BLV): minimum dose of BLV-FLK cells and cell-free BLV and neutralization activity of natural antibodies = Infección experimental en ovinos con el virus de leucosis bovina: dosis mínima de células BLV-FLK y virus libre de células, y actividad neutralizante de anticuerpos naturales
(Elsevier España, 2019-12)Bovine leukemia virus (BLV) is an important cattle pathogen that causes major economic losses worldwide, especially in dairy farms. The use of animal models provides valuable insight into the pathogenesis of viral infections. ... -
Expression-based analysis of genes related to single nucleotide polymorphism hits associated with bovine leukemia virus proviral load in Argentinean dairy cattle
(Elsevier, 2021-02)In dairy cattle infected with bovine leukemia virus (BLV), the proviral load (PVL) level is directly related to the viral transmission from infected animals to their healthy herdmates. Two contrasting phenotypic groups can ... -
Influencia de las condiciones de incubación en la detección de anticuerpos contra el Virus de la Leucosis bovina por ELISA = Influence of the incubation conditions on the detection of antibodies to bovine leukemia virus by ELISA
(Sociedad de Medicina Veterinaria, 2013-05)En este trabajo se modificaron las condiciones de incubación del ensayo de ELISAp24 que detecta anticuerpos contra el Virus de la Leucosis bovina, con el propósito de evaluar si se reduce el número de resultados falsos y ... -
Recent advances in BLV research
(MDPI, 2015-11)Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and ... -
Seroprevalence and risk factors associated with bovine Leukemia virus infection in argentine beef cattle
(Elsevier, 2023-11)Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, an endemic disease in dairy cattle of Argentina. However, little is known about the seroprevalence of BLV in beef cattle. In this study, we ... -
Seroprevalencia de leucosis enzoótica bovina en tambos del sur de la provincia de Córdoba, Argentina = Seroprevalence of enzootic bovine leucosis in dairy farms in the south of the province of Córdoba, Argentina
(2019-03)La Leucosis Enzoótica Bovina (LEB) afecta al tejido linfoide y el rasgo patológico distintivo es la transformación neoplásica de linfocitos B, su frecuencia es predominante en el ganado lechero adulto. Existen pocos estudios ... -
Short communication: Relationship between the level of bovine leukemia virus antibody and provirus in blood and milk of cows from a naturally infected herd
(2016)We explored the relationship between the level of bovine leukemia virus antibodies and provirus load during natural infection. For that purpose, a set of 50 blood and milk paired samples were analyzed for the presence of ... -
Spontaneous virus reactivation in cattle chronically infected with bovine leukemia virus
(BioMed Central, 2019)Background: The absence of virus expression during the chronic stage of bovine leukemia virus (BLV) infection and its reactivation upon ex vivo culture has become a long-lived Dogma. During the chronic stage of BLV ... -
Stable infection of a bovine mammary epithelial cell line (MAC-T) with bovine leukemia virus (BLV)
(Elsevier, 2018)Bovine leukemia virus (BLV) is a retrovirus that affects cattle causing a lymphoproliferative disease. BLV infection has been associated with misbalance of the immune response causing a higher incidence of other infections. ...