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A DNA vaccine formulated with chemical adjuvant provides partial protection against bovine herpes virus infection in cattle
Quattrocchi, Valeria; Soria, Ivana; Langellotti, Cecilia Ana; Gnazzo, Victoria; Gammella, Mariela; Moore, Prando Dadin; Zamorano, Patricia Ines (2017-01-25)Bovine herpesvirus-1 (BoHV-1) is the causative agent of bovine infectious rhinotracheitis, an important disease worldwide. Although conventional BoHV-1 vaccines, including those based on the use of modified live virus and ... -
A new cage-like particle adjuvant enhances protection of foot-and-mouth disease vaccine
Bidart, Juan Esteban; Kornuta, Claudia Alejandra; Gammella, Mariela; Gnazzo, Victoria; Soria, Ivana; Langellotti, Cecilia Ana; Mongini, Claudia; Galarza, Roxana Ivon; Calvinho, Luis Fernando; Lupi, Giuliana; Quattrocchi, Valeria; Marcipar, Ivan; Zamorano, Patricia Ines (Frontiers Media, 2020-07)Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ... -
Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
Quattrocchi, Valeria; Molinari, Maria Paula; Langellotti, Cecilia Ana; Gnazzo, Victoria; Taboga, Oscar Alberto; Zamorano, Patricia Ines (Elsevier, 2013-05-31)Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were ... -
Immune Response and Partial Protection against Heterologous Foot-and-Mouth Disease Virus Induced by Dendrimer Peptides in Cattle
Soria, Ivana; Quattrocchi, Valeria; Langellotti, Cecilia Ana; Perez Filgueira, Daniel Mariano; Pega, Juan Franco; Gnazzo, Victoria; Romera, Sonia Alejandra; Schammas, Juan Manuel; Bucafusco, Danilo; Di Giacomo, Sebastián; García de la Torre, Beatriz; Andreu, David; Sobrino, Francisco; Blanco, Esther; Zamorano, Patricia Ines (2018-04)Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to ...