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Abstract
An oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published using a QuilA‐adjuvanted vaccine. Long‐term efficacy was also tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after the beginning [ver mas...]
dc.contributor.authorPoggio, Thelma Veronica
dc.contributor.authorJensen, Oscar
dc.contributor.authorMossello, M.
dc.contributor.authorIriarte, J.
dc.contributor.authorAvila, Héctor Gabriel
dc.contributor.authorGertiser, María Laura
dc.contributor.authorSerafino, J.J.
dc.contributor.authorRomero, Sandra Raquel
dc.contributor.authorEchenique, Marcelo Alejandro
dc.contributor.authorDominguez, D.E.
dc.contributor.authorBarrios, J.R.
dc.contributor.authorHeath, D.
dc.date.accessioned2018-08-01T17:24:07Z
dc.date.available2018-08-01T17:24:07Z
dc.date.issued2016-08
dc.identifier.issn0141-9838
dc.identifier.issn1365-3024
dc.identifier.otherhttps://doi.org/10.1111/pim.12325
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12325
dc.identifier.urihttp://hdl.handle.net/20.500.12123/2946
dc.description.abstractAn oil‐based formulation of the EG95 vaccine to protect grazing animals against infection with Echinococcus granulosus was formulated in Argentina. The efficacy of the vaccine was monitored by serology in sheep and llama (Lama glama) and was compared to the serology in sheep previously published using a QuilA‐adjuvanted vaccine. Long‐term efficacy was also tested in sheep by challenging with E. granulosus eggs of the G1 strain 4 years after the beginning of the trial. The serological results for both sheep and llama were similar to those described previously, except that there was a more rapid response after the first vaccination. A third vaccination given after 1 year resulted in a transient boost in serology that lasted for about 12 months, which was similar to results previously described. Sheep challenged after 4 years with three vaccinations presented 84·2% reduction of live cysts counts compared with control group, and after a fourth vaccination prior to challenge, this reduction was 94·7%. The oil‐based vaccine appeared to be bio‐equivalent to the QuilA vaccine.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceParasite Immunology 38 (8) : 496-502 (August 2016)es_AR
dc.subjectOvinoses_AR
dc.subjectSheepeng
dc.subjectLlamaes_AR
dc.subjectLlamaseng
dc.subjectEchinococcus granulosuses_AR
dc.subjectInmunidades_AR
dc.subjectImmunityeng
dc.subjectVacunaes_AR
dc.subjectVaccineseng
dc.subjectSerologíaes_AR
dc.subjectSerologyeng
dc.titleSerology and longevity of immunity against Echinococcus granulosus in sheep and llama induced by an oil‐based EG95 vaccinees_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEEA Abra Pampaes_AR
dc.description.filFil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; Argentinaes_AR
dc.description.filFil: Jensen, Oscar. Centro de Investigacion en Zoonosis; Argentinaes_AR
dc.description.filFil: Mossello, M.. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; Argentinaes_AR
dc.description.filFil: Iriarte, J. Gobierno de la Provincia de Chubut. Ministerio de Salud. Departamento Zooantroponosis; Argentinaes_AR
dc.description.filFil: Avila, Héctor Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentinaes_AR
dc.description.filFil: Gertiser, María Laura. Centro de Investigacion en Zoonosis; Argentinaes_AR
dc.description.filFil: Serafino, J.J. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología. Centro de Virologia Animal; Argentinaes_AR
dc.description.filFil: Romero, Sandra Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentinaes_AR
dc.description.filFil: Echenique, Marcelo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentinaes_AR
dc.description.filFil: Dominguez, D. E.. Gobierno de la Provincia de Chubut. Ministerio de Desarrollo Territorial y Sectores Productivos. Subsecretaría de Ganadería y Agricultura. Dirección de Sanidad Animal; Argentinaes_AR
dc.description.filFil: Barrios, J.R.. Servicio Nacional de Sanidad Animal (SENASA).cDirección de Sanidad Animal. Oficina Local Puerto Madryn; Argentinaes_AR
dc.description.filFil: Heath, D.. AgResearch; Nueva Zelandaes_AR
dc.subtypecientifico


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