Show simple item record

resumen

Abstract
Neospora caninum, an intracellular protozoan parasite from the phylum Apicomplexa, is the etiologic agent of neosporosis, a disease considered as a major cause of reproductive loss in cattle and neuromuscular disease in dogs. Bovine neosporosis has a great economic impact in both meat and dairy industries, related to abortion, premature culling and reduced milk yields. Although many efforts have been made to restrain bovine neosporosis, there are still no [ver mas...]
dc.contributor.authorMansilla, Florencia Celeste
dc.contributor.authorCapozzo, Alejandra
dc.date.accessioned2018-03-09T12:20:08Z
dc.date.available2018-03-09T12:20:08Z
dc.date.issued2017-12
dc.identifier.issn0014-4894 (Print)
dc.identifier.issn1090-2449 (Online)
dc.identifier.otherhttps://doi.org/10.1016/j.exppara.2017.10.009
dc.identifier.urihttp://hdl.handle.net/20.500.12123/2001
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0014489417301443
dc.description.abstractNeospora caninum, an intracellular protozoan parasite from the phylum Apicomplexa, is the etiologic agent of neosporosis, a disease considered as a major cause of reproductive loss in cattle and neuromuscular disease in dogs. Bovine neosporosis has a great economic impact in both meat and dairy industries, related to abortion, premature culling and reduced milk yields. Although many efforts have been made to restrain bovine neosporosis, there are still no efficacious control methods. Many vaccine-development studies focused in the apicomplexan proteins involved in the adhesion and invasion of the host cell. Among these proteins, profilins have recently emerged as potential vaccine antigens or even adjuvant candidates for several diseases caused by apicomplexan parasites. Profilins bind Toll-like receptors 11 and 12 initiating MyD88 signaling, that triggers IL-12 and IFN-g production, which may promote protection against infection. Here we summarized the state-of-the-art of novel vaccine development based on apicomplexan profilins applied as antigens or adjuvants, and delved into recent advances on N. caninum vaccines using profilin in the mouse model and in cattle.eng
dc.formatapplication/pdf
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceExperimental Parasitology 183 : 64-68 (December 2017)
dc.subjectEnfermedades de los Animales
dc.subjectAnimal Diseaseseng
dc.subjectVacunación
dc.subjectVaccinationeng
dc.subjectGanado Bovino
dc.subjectCattleeng
dc.subjectNeospora Caninum
dc.subjectSporozoa
dc.subject.otherApicomplexa
dc.titleApicomplexan profilins in vaccine development applied to bovine neosporosis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.description.origenInst.de Virología
dc.gic155627
dc.description.filFil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
dc.description.filFil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.subtypecientifico


Files in this item

Thumbnail

This item appears in the following Collection(s)

common

Show simple item record