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Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
Abstract
The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In
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The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway.
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![Thumbnail](/xmlui/bitstream/handle/20.500.12123/16601/feb2.v596.21.cover.jpg?sequence=4&isAllowed=y)
Author
Toscani, Andrés Martin;
Aguilera, Pablo Nicolás;
Coluccio Leskow, Federico;
Fuente
FEBS Letters 596 (21) : 2795-2807 (November 2022)
Date
2022-11
Editorial
Wiley
ISSN
1873-3468
Formato
pdf
Tipo de documento
artículo
Palabras Claves
Derechos de acceso
Restringido
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