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The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In
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dc.contributor.author | Toscani, Andrés Martin | |
dc.contributor.author | Aguilera, Pablo Nicolás | |
dc.contributor.author | Coluccio Leskow, Federico | |
dc.date.accessioned | 2024-02-14T15:04:08Z | |
dc.date.available | 2024-02-14T15:04:08Z | |
dc.date.issued | 2022-11 | |
dc.identifier.issn | 1873-3468 | |
dc.identifier.other | https://doi.org/10.1002/1873-3468.14522 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/16601 | |
dc.identifier.uri | https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14522 | |
dc.description.abstract | The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Wiley | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | FEBS Letters 596 (21) : 2795-2807 (November 2022) | es_AR |
dc.subject | Mammary Glands | eng |
dc.subject | Glándulas Mamarias | es_AR |
dc.subject | Genética | |
dc.subject | Genetics | eng |
dc.subject.other | Epithelial Cells | eng |
dc.subject.other | Células Epiteliales | es_AR |
dc.subject.other | Discoidin Domain Receptor | eng |
dc.subject.other | Receptor del Dominio Discoidina | es_AR |
dc.title | Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Toscani, Andrés Martin. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN); Argentina | es_AR |
dc.description.fil | Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Aguilera, Pablo Nicolás. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina | es_AR |
dc.description.fil | Fil: Aguilera, Pablo Nicolás. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Aguilera, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Coluccio Leskow, Federico. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina | es_AR |
dc.subtype | cientifico |
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