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Resumen
High-throughput sequencing of genomes has expanded our knowledge of the Alphaherpesvirinae, a widely extended subfamily of DNA viruses that recombine to increase their genetic diversity. It has been acknowledged that Equid herpesvirus 1 (EHV-1) and equid herpesvirus 4 (EHV-4), two alphaherpesviruses with an economic impact on the horse industry, can recombine. This work aimed to analyze interspecific recombination between all equid alphaherpesvirus
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dc.contributor.author | Tau, Rocio Lucia | |
dc.contributor.author | Ferreccio, Carola Maria | |
dc.contributor.author | Bachir, Natalia Veronica | |
dc.contributor.author | Torales, Fatima Anabel | |
dc.contributor.author | Romera, Sonia Alejandra | |
dc.contributor.author | Maidana, Silvina Soledad | |
dc.date.accessioned | 2023-09-21T16:40:21Z | |
dc.date.available | 2023-09-21T16:40:21Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0737-0806 | |
dc.identifier.other | https://doi.org/10.1016/j.jevs.2023.104916 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/15284 | |
dc.description.abstract | High-throughput sequencing of genomes has expanded our knowledge of the Alphaherpesvirinae, a widely extended subfamily of DNA viruses that recombine to increase their genetic diversity. It has been acknowledged that Equid herpesvirus 1 (EHV-1) and equid herpesvirus 4 (EHV-4), two alphaherpesviruses with an economic impact on the horse industry, can recombine. This work aimed to analyze interspecific recombination between all equid alphaherpesvirus species, using genomes of EHV-1, EHV-3, EHV-4, EHV-6, EHV-8, and EHV-9 available in GenBank. 14 events of recombination by RDP4 and Simplot between EHV-1 x EHV-4, EHV-1 x EHV-9, EHV-8 x EHV-1, and EHV-8 x EHV-9 were identified. 10 out of 14 events involved ORF64, a double-copy gene located at the repeat regions that codifies for the infected cell protein 4 (ICP4). Among the ICP4, recombination can be found between EHV-1 X EHV-9, EHV-8 X EHV-9, and EHV-1 X EHV-4, the former affects zebra-borne genotypes, a type of EHV-1 that infect wild equids, and the latter match with previous breakpoints reported in fields isolates. Consequently, these findings strongly suggest that ICP4 is a hotspot for recombination. This work describes novel recombination events and is the first genome-wide recombination analysis using all available equid alphaherpesvirus species genomes. | es_AR |
dc.format | application/pdf | eng |
dc.language.iso | eng | es_AR |
dc.publisher | Elsevier | es_AR |
dc.rights | info:eu-repo/semantics/embargoedAccess | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | eng |
dc.source | Journal of equine veterinary science (Available online 11 September 2023) | eng |
dc.subject | Herpesviridae | es_AR |
dc.subject | Homologous Recombination | eng |
dc.subject | Recombinación Homóloga | es_AR |
dc.subject | Equidae | es_AR |
dc.subject.other | Alphaherpesvirus | es_AR |
dc.title | Comprehensive analysis of equid herpesvirus recombination : an insight into the repeat regions | eng |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/acceptedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | eng |
dc.description.origen | Instituto de Virología | es_AR |
dc.description.fil | Fil: Tau, Rocio Lucia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Tau, Rocio Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Ferrecio, Carola Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación en Virología; Argentina | es_AR |
dc.description.fil | Fil: Ferrecio, Carola Maria. Consejo Nacional de Investigaciones Cientificas y Tecnicas; Argentina | es_AR |
dc.description.fil | Fil: Ferrecio, Carola Maria. Universidad del Salvador. Cátedra de Inmunología; Argentina | es_AR |
dc.description.fil | Fil: Bachir, Natalia Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Bachir, Natalia Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Torales, Fatima Anabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Torales, Fatima Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Romera, Sonia Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Romera, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Romera, Sonia Alejandra. Universidad del Salvador. Cátedra de Inmunología; Argentina | es_AR |
dc.description.fil | Fil: Maidana, Silvina Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Maidana, Silvina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Maidana, Silvina Soledad. Universidad del Salvador. Cátedra de Inmunología; Argentina | es_AR |
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