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Abstract
Retroviruses are not expected to encode miRNAs because of the potential problem of self-cleavage of their genomic RNAs. This assumption has recently been challenged by experiments showing that bovine leukemia virus (BLV) encodes miRNAs from intragenomic Pol III promoters. The BLV miRNAs are abundantly expressed in B-cell tumors in the absence of significant levels of genomic and subgenomic viral RNAs. Using deep RNA sequencing and functional reporter [ver mas...]
dc.contributor.authorGillet, Nicolas A.
dc.contributor.authorHamaidia, Malik
dc.contributor.authorBrogniez, Alix de
dc.contributor.authorGutierrez, Gerónimo
dc.contributor.authorRenotte, Nathalie
dc.contributor.authorReichert, Michal
dc.contributor.authorTrono, Karina Gabriela
dc.contributor.authorWillems, Luc
dc.date.accessioned2017-09-14T13:41:45Z
dc.date.available2017-09-14T13:41:45Z
dc.date.issued2016-04
dc.identifier.citationGillet NA, Hamaidia M, de Brogniez A, Gutiérrez G, Renotte N, Reichert M, et al. (2016) Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo. PLoS Pathog 12(4): e1005588
dc.identifier.issn1553-7366 (Print)
dc.identifier.issn1553-7374 (Online)
dc.identifier.otherhttps://doi.org/10.1371/journal.ppat.1005588
dc.identifier.urihttp://hdl.handle.net/20.500.12123/1218
dc.identifier.urihttp://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005588&type=printable
dc.description.abstractRetroviruses are not expected to encode miRNAs because of the potential problem of self-cleavage of their genomic RNAs. This assumption has recently been challenged by experiments showing that bovine leukemia virus (BLV) encodes miRNAs from intragenomic Pol III promoters. The BLV miRNAs are abundantly expressed in B-cell tumors in the absence of significant levels of genomic and subgenomic viral RNAs. Using deep RNA sequencing and functional reporter assays, we show that miRNAs mediate the expression of genes involved in cell signaling, cancer and immunity. We further demonstrate that BLV miRNAs are essential to induce B-cell tumors in an experimental model and to promote efficient viral replication in the natural host.eng
dc.formatapplication/pdf
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcePLOS Pathogens 12(4) : e1005588 (2016)
dc.subjectEnfermedades de los Animales
dc.subjectAnimal Diseaseseng
dc.subjectVirus Leucemia Bovina
dc.subjectBovine Leukaemia Viruseng
dc.subjectARN
dc.subjectRNAeng
dc.subjectOncogenicidad
dc.subjectOncogenicityeng
dc.titleBovine leukemia virus small noncoding RNAs are functional elements that regulate replication and contribute to oncogenesis in vivo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.description.origenInst.de Virología
dc.gic150730
dc.description.filFil: Gillet, Nicolas A. University of Liège. Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
dc.description.filFil: Hamaidia, Malik. University of Liège. Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
dc.description.filFil: Renotte, Nathalie. University of Liège. Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
dc.description.filFil: Reichert, Michal. National Veterinary Research Institute; Polonia
dc.description.filFil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
dc.description.filFil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
dc.description.filFil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
dc.subtypecientifico


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