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Abstract
Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to [ver mas...]
dc.contributor.authorHollmann, Axel
dc.contributor.authorCardoso, Nancy
dc.contributor.authorEspeche, Juan C.
dc.contributor.authorMaffía, Paulo C.
dc.date.accessioned2022-06-06T10:35:16Z
dc.date.available2022-06-06T10:35:16Z
dc.date.issued2021-08
dc.identifier.issn1873-5169
dc.identifier.otherhttps://doi.org/10.1016/j.peptides.2021.170570
dc.identifier.urihttp://hdl.handle.net/20.500.12123/12019
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0196978121000784
dc.description.abstractViruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junín virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed. Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourcePeptides 142 : 170570 (Agosto 2021)es_AR
dc.subjectPeptideseng
dc.subjectPéptidoses_AR
dc.subjectAntiviral Agentseng
dc.subjectViricidases_AR
dc.subjectZoonoseseng
dc.subjectZoonosises_AR
dc.subjectAnimal Viruseseng
dc.subjectVirus de los Animaleses_AR
dc.subjectCOVID-19es_AR
dc.titleReview of antiviral peptides for use against zoonotic and selected non-zoonotic viruseses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Virologíaes_AR
dc.description.filFil: Hollmann, Axel. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; Argentinaes_AR
dc.description.filFil: Hollmann, Axel. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentinaes_AR
dc.description.filFil: Hollmann, Axel. Universidad Nacional de Quilmes. Instituto de Microbiología Básica y Aplicada. Laboratorio de Microbiología Molecular; Argentinaes_AR
dc.description.filFil: Cardoso, Nancy. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentinaes_AR
dc.description.filFil: Cardoso, Nancy. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentinaes_AR
dc.description.filFil: Espeche, Juan C. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; Argentinaes_AR
dc.description.filFil: Espeche, Juan C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentinaes_AR
dc.description.filFil: Maffía, Paulo C. Universidad Nacional de Hurlingham. Instituto de Biotecnología; Argentinaes_AR
dc.description.filFil: Maffía, Paulo C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentinaes_AR
dc.subtypecientifico


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