Temas
Mostrando ítems 1-20 de 83
-
A DNA vaccine formulated with chemical adjuvant provides partial protection against bovine herpes virus infection in cattle
(2017-01-25)Bovine herpesvirus-1 (BoHV-1) is the causative agent of bovine infectious rhinotracheitis, an important disease worldwide. Although conventional BoHV-1 vaccines, including those based on the use of modified live virus and ... -
A new gnotobiotic pig model of P[6] human rotavirus infection and disease for preclinical evaluation of rotavirus vaccines
(MDPI, 2022-12)Human rotavirus (HRV) is a leading cause of gastroenteritis in children under 5 years of age. Licensed vaccines containing G1P[8] and G1-4P[8] strains are less efficacious against newly emerging P[6] strains, indicating ... -
A novel MHC-II targeted BVDV subunit vaccine induces a neutralizing immunological response in guinea pigs and cattle
(Wiley, 2021-11)Bovine viral diarrhoea virus (BVDV) is a major cause of economic loss in the cattle industry, worldwide. Infection results in reduced productive performance, growth retardation, reduced milk production and increased ... -
A Novel Vaccine for Bovine Diarrhea Complex Utilizing Recombinant Enterotoxigenic Escherichia coli and Salmonella Expressing Surface-Displayed Chimeric Antigens from Enterohemorrhagic Escherichia coli O157:H7
(MDPI, 2025-02)Background/Objectives: Enterohemorrhagic Escherichia coli (EHEC) O157:H7, a zoonotic pathogen primarily found in cattle, causes Hemolytic Uremic Syndrome (HUS) in humans, often through contaminated food. Its Type Three ... -
Accuracy of traditional and novel serology tests for predicting cross-protection in foot-and-mouth disease vaccinated cattle
(Elsevier, 2014-01-16)Foot-and-mouth disease virus (FMDV) antigenic-match between vaccine and field viruses has traditionally been estimated in vitro by computing the r1 value using virus neutralization test (VNT) or ELISA titers. In this study ... -
Advances in novel vaccines for foot and mouth disease: focus on recombinant empty capsids
(Taylor & Francis, 2019-05)Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals, which causes severe economic losses in the livestock industry. Currently available vaccines are based on inactivated FMD virus (FMDV). ... -
An efficient vaccine against bovine leukemia virus
(BioMed Central, 2015)Previous attempts to produce a vaccine against BLV faced problems of efficacy (i.e. only a fraction of animals were protected), persistence (i.e. rapid decrease of immune protection), cost (e.g. production of purified ... -
An oral salmonella-based vaccine inhibits liver metastases by promoting tumor-specific T-cell-mediated immunity in celiac and portal lymph nodes : a preclinical study
(2016)Primary tumor excision is one of the most widely used therapies of cancer. However, the risk of metastases development still exists following tumor resection. The liver is a common site of metastatic disease for numerous ... -
Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles
(Elsevier, 2019-12)Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic ... -
Application of serological tests to assess the efficacy of foot-and-mouth disease vaccination in dairy cattle with or without viral leucosis
(Juniper Publishers, 2018-12)Enzootic bovine leucosis is an infectious viral disease of cattle distributed worldwide that affect dairy cattle over 2 years of age. This disease produces changes in the animal´s immune system that may affect vaccine ... -
Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle
(MDPI, 2022-08)Foot-and-mouth disease (FMD) remains one of the major threats to animal health worldwide. Its causative agent, the FMD virus (FMDV), affects cloven-hoofed animals, including farm animals and wildlife species, inflicting ... -
Bovine colostral cells—the often forgotten component of colostrum
(American Veterinary Medical Association, 2017-05)At birth, neonatal calves have all the essential immune components they need as adult cattle; however, it takes at least 2 to 4 weeks for those components to become fully functional.1,2 The immune system does not become ... -
Characterization of GASA-1, a new vaccine candidate antigen of Babesia bovis
(Elsevier, 2020-11)Surface proteins bound to the cell membrane by glycosylphosphatidylinositol (GPI) anchors are considered essential for the survival of pathogenic protozoans. In the case of the tick-transmitted hemoparasite Babesia bovis, ... -
Co-inoculation of baculovirus and FMDV vaccine in mice, elicits very early protection against foot and mouth disease virus without interfering with long lasting immunity
(Elsevier, 2013-05-31)Baculoviruses (Bvs) potentiate the immune response against soluble antigens. We investigated whether Bv could be used as immunoactivator in foot-and-mouth disease (FMD) vaccines using the BALB/c mouse model. Mice were ... -
Combined live oral priming and intramuscular boosting regimen with Rotarix® and a nanoparticle-based trivalent rotavirus vaccine evaluated in gnotobiotic pig models of G4P[6] and G1P[8] human rotavirus infection
(MDPI, 2023-05)Human rotavirus (HRV) is the causative agent of severe dehydrating diarrhea in children under the age of five, resulting in up to 215,000 deaths each year. These deaths almost exclusively occur in low- and middle-income ... -
Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma
(Elsevier, 2019-03)Exosomes are 60–150 nm small extracellular vesicles (EVs) released by most cells. Tumor-cell-derived exosomes, used as a vaccine, elicit a specific cytotoxic response against tumor cells, usually with a greater immunogenicity ... -
Degrade to survive : the intricate world of piroplasmid proteases
(Elsevier, 2023-07)Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate ... -
Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-Cell responses
(2016-05)MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity ... -
Desarrollo de candidatos vacunales contra Babesia bovis basados en vectores virales y proteínas recombinantes
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2016-09)La babesiosis bovina es una enfermedad parasitaria trasmitida por garrapatas y causada por los protozooarios intraeritrocíticos Babesia bovis y B. bigemina. Esta infección provoca importantes pérdidas económicas en varias ... -
Desarrollo y evaluación de tecnología para la detección de proteínas no estructurales del Virus de la Fiebre Aftosa en formulaciones vacunales
(Universidad Nacional de San Martín, 2009)La fiebre aftosa (FA) es una enfermedad viral altamente contagiosa que afecta a todas las especies de pezuña hendida, salvajes y domésticas. Las especies domésticas principalmente afectadas son los bovinos, porcinos, ovinos ...