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Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
Marcucci, Carolina; Rademacher, Marina; Kamecki, Fabiola; Pastore, Velentina; Bach, Hernán Gerónimo; Ricco, Rafael Alejandro; Wagner, Marcelo Luis; Knez, Damijan; Gobec, Stanislav; Colettis, Natalia; Mander, Mariel (MDPI, 2023-01-01)Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly ... -
Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species
Marcucci, Carolina; Anselmi Relats, Juan Manuel; Bach, Hernán Gerónimo; Kamecki, Fabiola; Varela, Beatriz Graciela; Wagner, Marcelo L.; Pastore, Valentina; Colettis, Natalia; Ricco, Rafael A.; Marder, Mariel (Elsevier, 2020-12)Folkloric or galenic preparations of valerian roots and rhizomes have been used as sedatives/anxiolytics and sleep inducers since ancient times. “Valerianas” are plants that naturally grow in our region. Although some of ...