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Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from the United Kingdom, South Korea, Brazil, and the United States revealed four novel large-scale structural variations of at least 2,000 bp. A comparative phylogenomic study including 2,483 core genes of 38 taxa from eight countries showed conflicting phylogenetic
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dc.contributor.author | Patané, José S.L. | |
dc.contributor.author | Martins Jr, Joaquim | |
dc.contributor.author | Castelão, Ana Beatriz C. | |
dc.contributor.author | Nishibe, Christiane | |
dc.contributor.author | Montera, Luciana | |
dc.contributor.author | Bigi, Fabiana | |
dc.contributor.author | Zumarraga, Martin Jose | |
dc.contributor.author | Cataldi, Angel Adrian | |
dc.contributor.author | Fonseca Junior, Antônio | |
dc.contributor.author | Roxo, Eliana | |
dc.contributor.author | Osório, Ana Luiza Alves Rosa | |
dc.contributor.author | Jorge, Klaudia dos Santos Goncalves | |
dc.contributor.author | Thacker, Tyler C. | |
dc.contributor.author | Almeida, Nalvo Franco | |
dc.contributor.author | Araujo, Flabio Ribeiro de | |
dc.contributor.author | Setubal, Joâo C. | |
dc.date.accessioned | 2020-11-06T16:39:40Z | |
dc.date.available | 2020-11-06T16:39:40Z | |
dc.date.issued | 2017-03 | |
dc.identifier.issn | 1759-6653 | |
dc.identifier.other | https://doi.org/10.1093/gbe/evx022 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/8210 | |
dc.identifier.uri | https://academic.oup.com/gbe/article/9/3/521/2992613 | |
dc.description.abstract | Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from the United Kingdom, South Korea, Brazil, and the United States revealed four novel large-scale structural variations of at least 2,000 bp. A comparative phylogenomic study including 2,483 core genes of 38 taxa from eight countries showed conflicting phylogenetic signal among sites. By minimizing this effect, we obtained a tree that better agrees with sampling locality. Results supported a relatively basal position of African strains (all isolated from Homo sapiens), confirming that Africa was an important region for early diversification and that humans were one of the earliest hosts. Selection analyses revealed that functional categories such as “Lipid transport and metabolism,” “Cell cycle control, cell division, chromosome partitioning” and “Cell motility” were significant for the evolution of the group, besides other categories previously described, showing importance of genes associated with virulence and cholesterol metabolism in the evolution of M. bovis. PE/PPE genes, many of which are known to be associated with virulence, were major targets for large-scale polymorphisms, homologous recombination, and positive selection, evincing for the first time a plethora of evolutionary forces possibly contributing to differential adaptability in M. bovis. By assuming different priors, US strains originated and started to diversify around 150–5,210 ya. By further analyzing the largest set of US genomes to date (76 in total), obtained from 14 host species, we detected that hosts were not clustered in clades (except for a few cases), with some faster-evolving strains being detected, suggesting fast and ongoing reinfections across host species, and therefore, the possibility of new bovine tuberculosis outbreaks. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Oxford University Press | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Genome Biology and Evolution 9 (3) : 521-535 (March 2017) | es_AR |
dc.subject | Mycobacterium bovis | es_AR |
dc.subject | Tuberculosis | es_AR |
dc.subject | Phylogeny | eng |
dc.subject | Filogenia | es_AR |
dc.subject | Epidemiology | eng |
dc.subject | Epidemiología | es_AR |
dc.title | Patterns and processes of mycobacterium bovis evolution revealed by phylogenomic analyses | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Patané, José S. L. Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica; Brasil | es_AR |
dc.description.fil | Fil: Martins Jr, Joaquim. Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica; Brasil | es_AR |
dc.description.fil | Fil: Castelão, Ana Beatriz C. Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia; Brasil | es_AR |
dc.description.fil | Fil: Nishibe, Christiane. Universidade Federal de Mato Grosso do Sul. Faculdade de Computação; Brasil | es_AR |
dc.description.fil | Fil: Montera, Luciana. Universidade Federal de Mato Grosso do Sul. Faculdade de Computação; Brasil | es_AR |
dc.description.fil | Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina | es_AR |
dc.description.fil | Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina | es_AR |
dc.description.fil | Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina | es_AR |
dc.description.fil | Fil: Fonseca Junior, Antônio. Rede de Laboratórios Agropecuários do Ministério da Agricultura, Pecuária e Abastecimento, Pedro Leopoldo; Brasil | es_AR |
dc.description.fil | Fil: Roxo, Eliana. Instituto Biológico de São Paulo; Brasil | es_AR |
dc.description.fil | Fil: Osório, Ana Luiza Alves Rosa. Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia. Programa de Pós-graduação em Ciência Animal; Brasil | es_AR |
dc.description.fil | Fil: Jorge, Klaudia dos Santos Goncalves. Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia. Programa de Pós-graduação em Ciência Animal; Brasil | es_AR |
dc.description.fil | Fil: Thacker, Tyler C. United States Department of Agriculture. Agricultural Research Service. National Animal Disease Center; Estados Unidos | es_AR |
dc.description.fil | Fil: Almeida, Nalvo F. Universidade Federal de Mato Grosso do Sul. Faculdade de Computação; Brasil | es_AR |
dc.description.fil | Fil: Araujo, Flabio Ribeiro de. Empresa Brasileira de Pesquisa Agropecuária (Embrapa). Gado de Corte; Brasil | es_AR |
dc.description.fil | Fil: Setubal, Joâo C. Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica; Brasil. Biocomplexity Institute of Virginia Tech; Estados Unidos | es_AR |
dc.subtype | cientifico |
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