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resumen

Resumen
Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the [ver mas...]
dc.contributor.authorBos, Kirsten I.
dc.contributor.authorHarkins, Kelly M.
dc.contributor.authorHerbig, Alexander
dc.contributor.authorCoscolla, Mireia
dc.contributor.authorWeber, Nico
dc.contributor.authorComas, Iñaki
dc.contributor.authorForrest, Stephen A.
dc.contributor.authorBryant, Josephine M.
dc.contributor.authorHarris, Simon R.
dc.contributor.authorSchuenemann, Verena J.
dc.contributor.authorCampbell, Tessa J.
dc.contributor.authorMajander, Kerrtu
dc.contributor.authorWilbur, Alicia K.
dc.contributor.authorGuichon, Ricardo A.
dc.contributor.authorSteadman, Dawnie L. Wolfe
dc.contributor.authorCook, Della Collins
dc.contributor.authorNiemann, Stefan
dc.contributor.authorBehr, Marcel A.
dc.contributor.authorZumarraga, Martin Jose
dc.contributor.authorBastida, Ricardo
dc.contributor.authorHuson, Daniel
dc.contributor.authorNieselt, Kay
dc.contributor.authorYoung, Douglas
dc.contributor.authorParkhill, Julian
dc.contributor.authorBuikstra, Jane E.
dc.contributor.authorGagneux, Sebastien
dc.contributor.authorStone, Anne C.
dc.contributor.authorKrause, Johannes
dc.date.accessioned2020-11-02T17:48:51Z
dc.date.available2020-11-02T17:48:51Z
dc.date.issued2014-08
dc.identifier.issn1476-4687
dc.identifier.otherhttps://doi.org/10.1038/nature13591
dc.identifier.urihttp://hdl.handle.net/20.500.12123/8175
dc.identifier.urihttps://www.nature.com/articles/nature13591
dc.description.abstractModern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherSpringer Naturees_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceNature 514 : 494-497 (Agosto 2014)es_AR
dc.subjectTuberculosises_AR
dc.subjectMycobacterium tuberculosis Infectionseng
dc.subjectInfección Mycobacterium tuberculosises_AR
dc.subjectGenomeseng
dc.subjectGenomases_AR
dc.subjectHuman Diseaseseng
dc.subjectEnfermedades Humanases_AR
dc.titlePre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosises_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Biotecnologíaes_AR
dc.description.filFil: Bos, Kirsten I. University of Tübingen. Department of Archaeological Sciences; Alemaniaes_AR
dc.description.filFil: Harkins, Kelly M. Arizona State University. School of Human Evolution and Social Change; Estados Unidoses_AR
dc.description.filFil: Herbig, Alexander. University of Tübingen. Department of Archaeological Sciences; Alemaniaes_AR
dc.description.filFil: Coscolla, Mireia. Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology; Suiza. University of Basel; Suizaes_AR
dc.description.filFil: Weber, Nico. University of Tübingen. Center for Bioinformatics; Alemaniaes_AR
dc.description.filFil: Comas, Iñaki. FISABIO-Public Health. Genomics and Health Unit; España. Centros de Investigación Biomédica en Red (CIBER) in Epidemiology and Public Health. Instituto de Salud Carlos III; Españaes_AR
dc.description.filFil: Forrest, Stephen A. University of Tübingen. Department of Archaeological Sciences; Alemaniaes_AR
dc.description.filFil: Bryant, Josephine M. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unidoes_AR
dc.description.filFil: Harris, Simon R. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unidoes_AR
dc.description.filFil: Schuenemann, Verena J. University of Tübingen. Department of Archaeological Sciences; Alemaniaes_AR
dc.description.filFil: Campbell, Tessa J. University of Cape Town. Department of Archaeology; Sudáfricaes_AR
dc.description.filFil: Majander, Kerrtu. University of Tübingen. Department of Archaeological Sciences; Alemaniaes_AR
dc.description.filFil: Wilbur, Alicia K. Arizona State University. School of Human Evolution and Social Change; Estados Unidoses_AR
dc.description.filFil: Guichon, Ricardo A. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Sociales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Steadman, Dawnie L. Wolfe. University of Tennessee. Department of Anthropology; Estados Unidoses_AR
dc.description.filFil: Cook, Della Collins. Indiana University. Department of Anthropology; Estados Unidoses_AR
dc.description.filFil: Niemann, Stefan. Forschungszentrum Borste. Molecular Mycobacteriology; Alemania. Forschungszentrum Borstel. German Center for Infection Research; Alemaniaes_AR
dc.description.filFil: Behr, Marcel A. McGill University. McGill International TB Centre; Canadáes_AR
dc.description.filFil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.description.filFil: Bastida, Ricardo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Huson, Daniel. University of Tübingen. Center for Bioinformatics; Alemaniaes_AR
dc.description.filFil: Nieselt, Kay. University of Tübingen. Center for Bioinformatics; Alemaniaes_AR
dc.description.filFil: Young, Douglas. Imperial College. Department of Medicine; Reino Unido. MRC National Institute for Medical Research. Division of Mycobacterial Research; Reino Unidoes_AR
dc.description.filFil: Parkhill, Julian. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unidoes_AR
dc.description.filFil: Buikstra, Jane E. Arizona State University. School of Human Evolution and Social Change; Estados Unidoses_AR
dc.description.filFil: Gagneux, Sebastien. Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology; Suiza. University of Basel; Suizaes_AR
dc.description.filFil: Stone, Anne C. Arizona State University. School of Human Evolution and Social Change; Estados Unidoses_AR
dc.description.filFil: Krause, Johannes. University of Tübingen. Senckenberg Centre for Human Evolution and Palaeoenvironment; Alemania. Max Planck Institute for Science and History; Alemaniaes_AR
dc.subtypecientifico


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