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Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the
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dc.contributor.author | Bos, Kirsten I. | |
dc.contributor.author | Harkins, Kelly M. | |
dc.contributor.author | Herbig, Alexander | |
dc.contributor.author | Coscolla, Mireia | |
dc.contributor.author | Weber, Nico | |
dc.contributor.author | Comas, Iñaki | |
dc.contributor.author | Forrest, Stephen A. | |
dc.contributor.author | Bryant, Josephine M. | |
dc.contributor.author | Harris, Simon R. | |
dc.contributor.author | Schuenemann, Verena J. | |
dc.contributor.author | Campbell, Tessa J. | |
dc.contributor.author | Majander, Kerrtu | |
dc.contributor.author | Wilbur, Alicia K. | |
dc.contributor.author | Guichon, Ricardo A. | |
dc.contributor.author | Steadman, Dawnie L. Wolfe | |
dc.contributor.author | Cook, Della Collins | |
dc.contributor.author | Niemann, Stefan | |
dc.contributor.author | Behr, Marcel A. | |
dc.contributor.author | Zumarraga, Martin Jose | |
dc.contributor.author | Bastida, Ricardo | |
dc.contributor.author | Huson, Daniel | |
dc.contributor.author | Nieselt, Kay | |
dc.contributor.author | Young, Douglas | |
dc.contributor.author | Parkhill, Julian | |
dc.contributor.author | Buikstra, Jane E. | |
dc.contributor.author | Gagneux, Sebastien | |
dc.contributor.author | Stone, Anne C. | |
dc.contributor.author | Krause, Johannes | |
dc.date.accessioned | 2020-11-02T17:48:51Z | |
dc.date.available | 2020-11-02T17:48:51Z | |
dc.date.issued | 2014-08 | |
dc.identifier.issn | 1476-4687 | |
dc.identifier.other | https://doi.org/10.1038/nature13591 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/8175 | |
dc.identifier.uri | https://www.nature.com/articles/nature13591 | |
dc.description.abstract | Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Springer Nature | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.source | Nature 514 : 494-497 (Agosto 2014) | es_AR |
dc.subject | Tuberculosis | es_AR |
dc.subject | Mycobacterium tuberculosis Infections | eng |
dc.subject | Infección Mycobacterium tuberculosis | es_AR |
dc.subject | Genomes | eng |
dc.subject | Genomas | es_AR |
dc.subject | Human Diseases | eng |
dc.subject | Enfermedades Humanas | es_AR |
dc.title | Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Bos, Kirsten I. University of Tübingen. Department of Archaeological Sciences; Alemania | es_AR |
dc.description.fil | Fil: Harkins, Kelly M. Arizona State University. School of Human Evolution and Social Change; Estados Unidos | es_AR |
dc.description.fil | Fil: Herbig, Alexander. University of Tübingen. Department of Archaeological Sciences; Alemania | es_AR |
dc.description.fil | Fil: Coscolla, Mireia. Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology; Suiza. University of Basel; Suiza | es_AR |
dc.description.fil | Fil: Weber, Nico. University of Tübingen. Center for Bioinformatics; Alemania | es_AR |
dc.description.fil | Fil: Comas, Iñaki. FISABIO-Public Health. Genomics and Health Unit; España. Centros de Investigación Biomédica en Red (CIBER) in Epidemiology and Public Health. Instituto de Salud Carlos III; España | es_AR |
dc.description.fil | Fil: Forrest, Stephen A. University of Tübingen. Department of Archaeological Sciences; Alemania | es_AR |
dc.description.fil | Fil: Bryant, Josephine M. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido | es_AR |
dc.description.fil | Fil: Harris, Simon R. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido | es_AR |
dc.description.fil | Fil: Schuenemann, Verena J. University of Tübingen. Department of Archaeological Sciences; Alemania | es_AR |
dc.description.fil | Fil: Campbell, Tessa J. University of Cape Town. Department of Archaeology; Sudáfrica | es_AR |
dc.description.fil | Fil: Majander, Kerrtu. University of Tübingen. Department of Archaeological Sciences; Alemania | es_AR |
dc.description.fil | Fil: Wilbur, Alicia K. Arizona State University. School of Human Evolution and Social Change; Estados Unidos | es_AR |
dc.description.fil | Fil: Guichon, Ricardo A. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Sociales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Steadman, Dawnie L. Wolfe. University of Tennessee. Department of Anthropology; Estados Unidos | es_AR |
dc.description.fil | Fil: Cook, Della Collins. Indiana University. Department of Anthropology; Estados Unidos | es_AR |
dc.description.fil | Fil: Niemann, Stefan. Forschungszentrum Borste. Molecular Mycobacteriology; Alemania. Forschungszentrum Borstel. German Center for Infection Research; Alemania | es_AR |
dc.description.fil | Fil: Behr, Marcel A. McGill University. McGill International TB Centre; Canadá | es_AR |
dc.description.fil | Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina | es_AR |
dc.description.fil | Fil: Bastida, Ricardo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Huson, Daniel. University of Tübingen. Center for Bioinformatics; Alemania | es_AR |
dc.description.fil | Fil: Nieselt, Kay. University of Tübingen. Center for Bioinformatics; Alemania | es_AR |
dc.description.fil | Fil: Young, Douglas. Imperial College. Department of Medicine; Reino Unido. MRC National Institute for Medical Research. Division of Mycobacterial Research; Reino Unido | es_AR |
dc.description.fil | Fil: Parkhill, Julian. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido | es_AR |
dc.description.fil | Fil: Buikstra, Jane E. Arizona State University. School of Human Evolution and Social Change; Estados Unidos | es_AR |
dc.description.fil | Fil: Gagneux, Sebastien. Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology; Suiza. University of Basel; Suiza | es_AR |
dc.description.fil | Fil: Stone, Anne C. Arizona State University. School of Human Evolution and Social Change; Estados Unidos | es_AR |
dc.description.fil | Fil: Krause, Johannes. University of Tübingen. Senckenberg Centre for Human Evolution and Palaeoenvironment; Alemania. Max Planck Institute for Science and History; Alemania | es_AR |
dc.subtype | cientifico |
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