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Abstract
The present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were [ver mas...]
dc.contributor.authorMartinez, Agustin
dc.contributor.authorCook, Daniel
dc.contributor.authorLee, Stephen T.
dc.contributor.authorSola, Diego
dc.contributor.authorBain, Luciana
dc.contributor.authorBorrelli, Laura Beatriz
dc.contributor.authorAcín, Cristina
dc.contributor.authorGardner, Dale R.
dc.contributor.authorRobles, Carlos Alejandro
dc.date.accessioned2020-08-25T11:37:08Z
dc.date.available2020-08-25T11:37:08Z
dc.date.issued2020-10-30
dc.identifier.issn0041-0101
dc.identifier.otherhttps://doi.org/10.1016/j.toxicon.2020.08.004
dc.identifier.urihttp://hdl.handle.net/20.500.12123/7765
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0041010120303445
dc.description.abstractThe present study describes the spontaneous and experimental poisoning of goats by Festuca argentina in Argentine Patagonia. In April 2017, eight seven-month-old Creole male goats were accidentally introduced into a paddock that contained F. argentina. After four days, two of the goats were found dead and four out of the six remaining goats were clinically affected. Two of the latter had to be later euthanized in extremis. The main clinical signs were progressive nervous signs, starting with moderate muscle tremors, wide-based stance and ataxia. Postmortem examination was performed on the two euthanized goats. Epidermal fragments of F. argentina were found in the rumen samples from the necropsied goats and the fecal samples from the four affected goats. For the experimental poisoning, fresh sheaths of F. argentina collected from the paddock were offered to two goats at 10 g/kg body weight for 3 days. After 24–36 h, both animals exhibited severe muscle tremors, reluctance to move, tetanic convulsions, and opisthotonus. In both the spontaneously and experimentally poisoned goats, gross lesions were similar and consisted of dehydration, petechial hemorrhages in the epicardium and congestion. The main microscopic findings consisted of degeneration and loss of Purkinje cells and torpedoes in the granular layer of the cerebellum. The F. argentina sheaths collected from the pasture were found to contain tremorgenic indole-diterpene alkaloids. Taken together, the results of the present study suggest that the tremorgenic syndrome observed in the spontaneously poisoned goats was due to poisoning by F. argentina.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceToxicon 186 : 191-197 (Octubre 2020)es_AR
dc.subjectEnvenenamientoes_AR
dc.subjectPoisoningeng
dc.subjectToxicidad por Ingestiónes_AR
dc.subjectIngestion Toxicityeng
dc.subjectFestucaes_AR
dc.subjectCabraes_AR
dc.subjectNannygoatseng
dc.subjectCaprinoses_AR
dc.subjectGoatseng
dc.subjectEnfermedades de los Animaleses_AR
dc.subjectAnimal Diseaseseng
dc.subject.otherRegión Patagónicaes_AR
dc.subject.otherFestuca Argentinaes_AR
dc.subject.otherCabras Criollases_AR
dc.titleFatal stagger poisoning by consumption of Festuca argentina (Speg.) Parodi in goats from Argentine Patagoniaes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEstación Experimental Agropecuaria Barilochees_AR
dc.description.filFil: Martinez, Agustin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentinaes_AR
dc.description.filFil: Cook, Daniel. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidoses_AR
dc.description.filFil: Lee, Stephen T. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidoses_AR
dc.description.filFil: Sola, Diego. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; Españaes_AR
dc.description.filFil: Bain, Luciana. Universidad Nacional del Centro de la Povincia de Buenos Aires; Argentinaes_AR
dc.description.filFil: Borrelli, Laura Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Laboratorio de Microhistología; Argentinaes_AR
dc.description.filFil: Acín, Cristina. Universidad de Zaragoza. Centro de Encefalopatías y Enfermedades Transmisibles Emergentes; Españaes_AR
dc.description.filFil: Gardner, Dale R. US Department of Agriculture. Agricultural Research Service (ARS). Poisonous Plant Research Laboratory; Estados Unidoses_AR
dc.description.filFil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentinaes_AR
dc.subtypecientifico


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