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resumen

Resumen
Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasmatic levels of corticosterone (Cor) via conflict behavior tests. To this aim, pups were separated daily from [ver mas...]
dc.contributor.authorOdeon, Maria Mercedes
dc.contributor.authorAcosta, Gabriela Beatriz
dc.date.accessioned2020-07-28T16:38:09Z
dc.date.available2020-07-28T16:38:09Z
dc.date.issued2019-12-29
dc.identifier.issn0278-5846
dc.identifier.otherhttps://doi.org/10.1016/j.pnpbp.2019.109726
dc.identifier.urihttp://hdl.handle.net/20.500.12123/7628
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S027858461930497X
dc.description.abstractAdverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasmatic levels of corticosterone (Cor) via conflict behavior tests. To this aim, pups were separated daily from their mothers for one hour and subjected to cold stress (4 °C) between postnatal days (PD) 2 and 20. Control groups were left undisturbed with their mothers. Afterwards, all groups were exposed to voluntary ethanol (6%) or dextrose (1%) intake for 7 days. After a 30-day period of environmental enrichment (EE), the animals were again exposed to the voluntary intake protocol for 7 days. At 66 days, they were subjected to different conflict tests. Thereafter, rats were sacrificed by decapitation and blood trunk was collected to determine plasma corticosterone levels. We demonstrated that early RMS increased both voluntary alcohol intake and Cor levels. Moreover, young adult animals showed excessive activity in conflict tests. Whereas in animals exposed to a non-pharmacological treatment, known as environmental enrichment (EE), the effects previously obtained were reversed and/or prevented. In summary, we can conclude that the combination of maternal separation in early life plus cold stress increase both the voluntary exposure to alcohol and disruptive behaviors. This is a risk factor for the development of chronic diseases such as alcoholism and long-term depression. However, we found that an enriched environment may have a beneficial effect with respect to alcohol intake and aggressive behaviors.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceProgress in Neuropsychopharmacology & Biological Psychiatry 95 : 109726 (2019)es_AR
dc.subjectRespuesta a la Selecciónes_AR
dc.subjectSelection Responseseng
dc.subjectEstrés de Fríoes_AR
dc.subjectCold Stresseng
dc.subjectTolerancia al Fríoes_AR
dc.subjectCold Toleranceeng
dc.subjectCorticosteronaes_AR
dc.subjectCorticosteroneeng
dc.subject.otherParamétros de Comportamientoes_AR
dc.titleRepeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatmentes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEstación Experimental Agropecuaria Barilochees_AR
dc.description.filFil: Odeon, Maria Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientıicas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentinaes_AR
dc.description.filFil: Acosta, Gabriela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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