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resumen

Resumen
Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through both inner and outer membranes to reach a potential target. Most secretion systems are harbored in mobile elements including transposons, plasmids, pathogenicity islands, and phages, and Escherichia coli is one of the more versatile [ver mas...]
dc.contributor.authorNavarro-García, Fernando
dc.contributor.authorRuiz-Perez, Fernando
dc.contributor.authorCataldi, Angel Adrian
dc.contributor.authorLarzabal, Mariano
dc.date.accessioned2019-10-30T17:30:58Z
dc.date.available2019-10-30T17:30:58Z
dc.date.issued2019-08
dc.identifier.issn1664-302X
dc.identifier.otherhttps://doi.org/10.3389/fmicb.2019.01965
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fmicb.2019.01965/full
dc.identifier.urihttp://hdl.handle.net/20.500.12123/6245
dc.description.abstractBacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through both inner and outer membranes to reach a potential target. Most secretion systems are harbored in mobile elements including transposons, plasmids, pathogenicity islands, and phages, and Escherichia coli is one of the more versatile bacteria adopting this genetic information by horizontal gene transfer. Additionally, E. coli is a bacterial species with members of the commensal intestinal microbiota and pathogens associated with numerous types of infections such as intestinal, urinary, and systemic in humans and other animals. T6SS cluster plasticity suggests evolutionarily divergent systems were acquired horizontally. T6SS is a secretion nanomachine that is extended through the bacterial double membrane; from this apparatus, substrates are conveyed straight from the cytoplasm of the bacterium into a target cell or to the extracellular space. This nanomachine consists of three main complexes: proteins in the inner membrane that are T4SS component-like, the baseplate complex, and the tail complex, which are formed by components evolutionarily related to contractile bacteriophage tails. Advances in the T6SS understanding include the functional and structural characterization of at least 13 subunits (so-called core components), which are thought to comprise the minimal apparatus. So far, the main role of T6SS is on bacterial competition by using it to kill neighboring non-immune bacteria for which antibacterial proteins are secreted directly into the periplasm of the bacterial target after cell–cell contact. Interestingly, a few T6SSs have been associated directly to pathogenesis, e.g., roles in biofilm formation and macrophage survival. Here, we focus on the advances on T6SS from the perspective of E. coli pathotypes with emphasis in the secretion apparatus architecture, the mechanisms of pathogenicity of effector proteins, and the events of lateral gene transfer that led to its spread.es_AR
dc.formatapplication/pdfeng
dc.language.isoeng
dc.publisherFrontiers Media
dc.rightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceFrontiers in microbiology 10 : 1965. (30 August 2019)es_AR
dc.subjectDiarrhoeaeng
dc.subjectDiarreaes_AR
dc.subjectEscherichia Colies_AR
dc.subjectPathogenicityeng
dc.subjectPatogenicidades_AR
dc.subjectVirulenceeng
dc.subjectVirulenciaes_AR
dc.subjectGene Transfereng
dc.subjectTransferencia de Geneses_AR
dc.titleType VI secretion system in pathogenic escherichia coli: structure, role in virulence, and acquisitiones_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.origenInstituto de Biotecnologíaes_AR
dc.description.filFil: Navarro-García, Fernando. Instituto Politécnico Nacional. Centro de Investigación y de Estudios Avanzados. Departamento de Biología Celular; Méxicoes_AR
dc.description.filFil: Ruiz-Perez, Fernando. University of Virginia School of Medicine. Department of Pediatrics; Estados Unidoses_AR
dc.description.filFil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Larzabal, Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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