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resumen

Resumen
Baculovirus occlusion-derived viruses (ODVs) and budded viruses (BVs) are morphologically and functionally distinct. ODVs are responsible for primary infection in insect hosts because of their high per os infectivity. On the contrary, BVs poorly infect endothelial gut cells, but propagate the infection in the tissues of insects with a high efficiency. P74 is one of the most important proteins from ODVs, and it participates in the attachment of this viral [ver mas...]
dc.contributor.authorAlfonso, Victoria
dc.contributor.authorLopez, Maria Gabriela
dc.contributor.authorCarrillo, Elisa Cristina
dc.contributor.authorTaboga, Oscar Alberto
dc.date.accessioned2019-05-15T13:53:09Z
dc.date.available2019-05-15T13:53:09Z
dc.date.issued2012-02
dc.identifier.issn0300-5526
dc.identifier.issn1423-0100
dc.identifier.otherhttps://doi.org/10.1159/000324538
dc.identifier.urihttps://www.karger.com/Article/Abstract/324538
dc.identifier.urihttp://hdl.handle.net/20.500.12123/5118
dc.description.abstractBaculovirus occlusion-derived viruses (ODVs) and budded viruses (BVs) are morphologically and functionally distinct. ODVs are responsible for primary infection in insect hosts because of their high per os infectivity. On the contrary, BVs poorly infect endothelial gut cells, but propagate the infection in the tissues of insects with a high efficiency. P74 is one of the most important proteins from ODVs, and it participates in the attachment of this viral phenotype to endothelial cells in the midgut. We evaluated the possibility of pseudotyping BVs of Autographa californica multiple nucleopolyhedrovirus with two versions of P74 and its effect on their oral infectivity. Both recombinant BVs contained P74 and replicated similarly to wild-type viruses. Nevertheless, the presence of P74 on the BV’s surface does not enhance the oral infectivity of this phenotype, suggesting that the presence of P74 in the membrane of budded virions interferes with their mechanism of infecting midgut cells.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherS. Karger AGes_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceIntervirology 55 (3) : 247–251. (February 2012)es_AR
dc.subjectViruses_AR
dc.subjectViruseseng
dc.subjectBaculoviridaees_AR
dc.subjectLepidopteraes_AR
dc.subjectAutographa californicaes_AR
dc.subjectPatogenicidades_AR
dc.subjectPathogenicityeng
dc.subjectFenotiposes_AR
dc.subjectPhenotypeseng
dc.subject.otherPoder infecciosoes_AR
dc.titleSurface Display of AcMNPV Occlusion-Derived P74 Does Not Enhance Oral Infectivity of Budded Viruseses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.origenInstituto de Biotecnologíaes_AR
dc.description.filFil: Alfonso, Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.description.filFil: Lopez, Maria Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina.es_AR
dc.description.filFil: Carrillo, Elisa Cristina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.description.filFil: Taboga, Oscar Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.subtypecientifico


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