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Abstract
Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having [ver mas...]
dc.contributor.authorRedondo, Leandro Martín
dc.contributor.authorDiaz Carrasco, Juan María
dc.contributor.authorRedondo, Enzo Alejandro
dc.contributor.authorDelgado, Fernando Oscar
dc.contributor.authorFernandez Miyakawa, Mariano Enrique
dc.date.accessioned2019-04-03T11:56:38Z
dc.date.available2019-04-03T11:56:38Z
dc.date.issued2015-03-23
dc.identifier.issn1932-6203
dc.identifier.otherhttps://doi.org/10.1371/journal.pone.0121305
dc.identifier.urihttp://hdl.handle.net/20.500.12123/4804
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121305
dc.description.abstractClostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment.eng
dc.formatapplication/pdfeng
dc.language.isoeng
dc.publisherPLOS
dc.rightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourcePLoS ONE 10 (3) : e0121305. (March 23, 2015)eng
dc.subjectClostridium Perfringenses_AR
dc.subjectVirulenciaes_AR
dc.subjectVirulenceeng
dc.subjectGastrointestinal Diseaseseng
dc.subjectEnfermedades Gastrointestinaleses_AR
dc.subjectBacteriocinseng
dc.subjectBacteriocinases_AR
dc.subjectEnteritises_AR
dc.subjectGut Colonizationeng
dc.subject.otherColonización Intestinales_AR
dc.titleClostridium perfringens type E virulence traits involved in gut colonizationeng
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.origenInstituto de Patobiologíaes_AR
dc.description.filFil: Redondo, Leandro Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Diaz Carrasco, Juan María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Redondo, Enzo Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentinaes_AR
dc.description.filFil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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