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Clostridium perfringens type E virulence traits involved in gut colonization

Abstract
Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having [ver mas...]
Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment. [Cerrar]
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Author
Redondo, Leandro Martín;   Diaz Carrasco, Juan María;   Redondo, Enzo Alejandro;   Delgado, Fernando Oscar;   Fernandez Miyakawa, Mariano Enrique;  
Fuente
PLoS ONE 10 (3) : e0121305. (March 23, 2015)
Date
2015-03-23
Editorial
PLOS
ISSN
1932-6203
URI
http://hdl.handle.net/20.500.12123/4804
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121305
DOI
https://doi.org/10.1371/journal.pone.0121305
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pdf
Tipo de documento
artículo
Palabras Claves
Clostridium Perfringens; Virulencia; Virulence; Gastrointestinal Diseases; Enfermedades Gastrointestinales; Bacteriocins; Bacteriocinas; Enteritis; Gut Colonization; Colonización Intestinal;
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Excepto donde se diga explicitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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