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resumen

Resumen
Staphylococcus aureus is a very successful opportunistic pathogen capable of causing a variety of diseases ranging from mild skin infections to life-threatening sepsis, meningitis and pneumonia. Its ability to display numerous virulence mechanisms matches its skill to display resistance to several antibiotics, including β-lactams, underscoring the fact that new anti-S. aureus drugs are urgently required. In this scenario, the utilization of lytic [ver mas...]
dc.contributor.authorAbatángelo, Virginia
dc.contributor.authorPeressutti Bacci, Natalia
dc.contributor.authorBoncompain, Carina A.
dc.contributor.authorAmadio, Ariel
dc.contributor.authorCarrasco, Soledad
dc.contributor.authorSuárez, Cristian A.
dc.contributor.authorMorbidoni, Héctor R.
dc.date.accessioned2019-03-27T12:16:10Z
dc.date.available2019-03-27T12:16:10Z
dc.date.issued2017-07
dc.identifier.issn1932-6203
dc.identifier.otherhttps://doi.org/10.1371/journal.pone.0181671
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181671
dc.identifier.urihttp://hdl.handle.net/20.500.12123/4752
dc.description.abstractStaphylococcus aureus is a very successful opportunistic pathogen capable of causing a variety of diseases ranging from mild skin infections to life-threatening sepsis, meningitis and pneumonia. Its ability to display numerous virulence mechanisms matches its skill to display resistance to several antibiotics, including β-lactams, underscoring the fact that new anti-S. aureus drugs are urgently required. In this scenario, the utilization of lytic bacteriophages that kill bacteria in a genus -or even species- specific way, has become an attractive field of study. In this report, we describe the isolation, characterization and sequencing of phages capable of killing S. aureus including methicillin resistant (MRSA) and multi-drug resistant S. aureus local strains from environmental, animal and human origin. Genome sequencing and bio-informatics analysis showed the absence of genes encoding virulence factors, toxins or antibiotic resistance determinants. Of note, there was a high similarity between our set of phages to others described in the literature such as phage K. Considering that reported phages were obtained in different continents, it seems plausible that there is a commonality of genetic features that are needed for optimum, broad host range anti-staphylococcal activity of these related phages. Importantly, the high activity and broad host range of one of our phages underscores its promising value to control the presence of S. aureus in fomites, industry and hospital environments and eventually on animal and human skin. The development of a cocktail of the reported lytic phages active against S. aureus–currently under way- is thus, a sensible strategy against this pathogen.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherPlos Onees_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourcePLoS ONE 12 (7) : e0181671 (July 2017)es_AR
dc.subjectStaphylococcus aureuses_AR
dc.subjectBacteriófagoses_AR
dc.subjectBacteriophageseng
dc.subjectVectores Genéticoses_AR
dc.subjectGenetic Vectorseng
dc.subjectSecuencia Nucleotídicaes_AR
dc.subjectNucleotide Sequenceeng
dc.titleBroad-range lytic bacteriophages that kill Staphylococcus aureus local field strainses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.origenEEA Rafaelaes_AR
dc.description.filFil: Abatángelo, Virginia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentinaes_AR
dc.description.filFil: Peressutti Bacci, Natalia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentinaes_AR
dc.description.filFil: Boncompain, Carina A. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentinaes_AR
dc.description.filFil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina.es_AR
dc.description.filFil: Carrasco, Soledad. Universidad Nacional de Rosario. Bioinformatics Program; Argentinaes_AR
dc.description.filFil: Suárez, Cristian A. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentinaes_AR
dc.description.filFil: Morbidoni, Héctor R. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentinaes_AR
dc.subtypecientifico


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