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Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity
Dib, Nahir; Fernández, Luciana; Santo, Marisa; Otero, Luis; Alustiza, Fabrisio Eduardo; Liaudat, Ana Cecilia; Bosch, Pablo; Lavaggi, María Laura; Cerecetto, Hugo; González, Mercedes Florencia (Elsevier, 2019-04-23)Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide. This compound ... -
Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems
Fernández, Luciana; Reviglio, Ana Lucía; Heredia, Daniel A.; Morales, Gustavo M.; Santo, Marisa; Otero, Luis; Alustiza, Fabrisio Eduardo; Liaudat, Ana Cecilia; Bosch, Pablo; Larghi, Enrique L.; Bracca, Andrea B.J.; Kaufman, Teodoro S. (Elsevier, 2021-03)Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a ...