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Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems

Abstract
Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were [ver mas...]
Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures. [Cerrar]
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Author
Fernández, Luciana;   Reviglio, Ana Lucía;   Heredia, Daniel A.;   Morales, Gustavo M.;   Santo, Marisa;   Otero, Luis;   Alustiza, Fabrisio Eduardo;   Liaudat, Ana Cecilia;   Bosch, Pablo;   Larghi, Enrique L.;   Bracca, Andrea B.J.;   Kaufman, Teodoro S.;  
Fuente
Heliyon 7 (3) : e06436 (March 2021)
Date
2021-03
Editorial
Elsevier
ISSN
2405-8440
URI
http://hdl.handle.net/20.500.12123/8902
https://www.sciencedirect.com/science/article/pii/S2405844021005417
DOI
https://doi.org/10.1016/j.heliyon.2021.e06436
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pdf
Tipo de documento
artículo
Palabras Claves
Cultivo de Células; Cell Culture; Compuestos Bioactivos; Bioactive Compounds; Sistemas de Administración de Drogas; Drug Delivery Systems; Transportadores de Fármacos; Drug Carriers;
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Excepto donde se diga explicitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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