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Abstract
The ability of Baculoviruses to hyper-express very late genes as polyhedrin, the major component of occlusion bodies (OBs) or polyhedra, has allowed the evolution of a system of great utility for biotechnology. The main function of polyhedra in nature is to protect Baculovirus in the environment. The possibility of incorporating foreign proteins into the crystal by fusing them to polyhedrin (POLH) opened novel potential biotechnological uses. In this [ver mas...]
dc.contributor.authorLopez, Maria Gabriela
dc.contributor.authorDiez, Michay
dc.contributor.authorAlfonso, Victoria
dc.contributor.authorTaboga, Oscar Alberto
dc.date.accessioned2019-02-18T13:15:59Z
dc.date.available2019-02-18T13:15:59Z
dc.date.issued2018-08
dc.identifier.issn0175-7598
dc.identifier.issn1432-0614 (Online)
dc.identifier.otherhttps://doi.org/10.1007/s00253-018-9130-2
dc.identifier.urihttp://hdl.handle.net/20.500.12123/4456
dc.description.abstractThe ability of Baculoviruses to hyper-express very late genes as polyhedrin, the major component of occlusion bodies (OBs) or polyhedra, has allowed the evolution of a system of great utility for biotechnology. The main function of polyhedra in nature is to protect Baculovirus in the environment. The possibility of incorporating foreign proteins into the crystal by fusing them to polyhedrin (POLH) opened novel potential biotechnological uses. In this review, we summarize different applications of Baculovirus chimeric OBs. Basically, the improvement of protein expression and purification with POLH as a fusion partner; the use of recombinant polyhedra as immunogens and antigens, and the incorporation of proteins into polyhedra to improve Baculoviruses as bioinsecticides. The results obtained in each area and the future trends in these topics are also discussed.eng
dc.formatapplication/pdfeng
dc.language.isoeng
dc.publisherSpringereng
dc.rightsinfo:eu-repo/semantics/restrictedAccesseng
dc.sourceApplied microbiology and biotechnology 102 (16) : 6765–6774. (August 2018)eng
dc.subjectBaculoviruses_AR
dc.subjectRecombinant Proteinseng
dc.subjectProteínas Recombinanteses_AR
dc.subjectBiotechnologyeng
dc.subjectBiotecnologíaes_AR
dc.subject.otherOcclusion Bodieseng
dc.subject.otherCuerpos de Oclusiónes_AR
dc.subject.otherBEVSeng
dc.subject.otherPolyhedrineng
dc.subject.otherPolihedrinaes_AR
dc.titleBiotechnological applications of occlusion bodies of Baculoviruseseng
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.description.origenInstituto de Biotecnologíaes_AR
dc.description.filFil: Lopez, Maria Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Diez, Michay. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.description.filFil: Alfonso, Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Taboga, Oscar Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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