Show simple item record

resumen

Abstract
Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the [ver mas...]
dc.contributor.authorBlanco, Federico Carlos
dc.contributor.authorSoria, Marcelo Abel
dc.contributor.authorKlepp, Laura Ines
dc.contributor.authorBigi, Fabiana
dc.date.accessioned2018-11-28T15:28:27Z
dc.date.available2018-11-28T15:28:27Z
dc.date.issued2017-12
dc.identifier.issn1660-2412
dc.identifier.otherhttps://doi.org/10.1159/000479183
dc.identifier.urihttps://www.karger.com/Article/Abstract/479183
dc.identifier.urihttp://hdl.handle.net/20.500.12123/3986
dc.description.abstractBovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherKargeres_AR
dc.relationinfo:eu-repograntAgreement/INTA/PNBIO/1131034/AR./Inmunología molecular y genómica funcional aplicadas a interacciones patógeno hospedador de interés pecuario.es_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceJournal of Molecular Microbiology and Biotechnology 27 (4) : 237-245 (Diciembre 2017)es_AR
dc.subjectTranscriptioneng
dc.subjectTranscripciónes_AR
dc.subjectMycobacterium bovises_AR
dc.subjectCattleeng
dc.subjectGanado Bovinoes_AR
dc.subjectImmune Responseeng
dc.subjectRespuesta Inmunológicaes_AR
dc.subjectTuberculosises_AR
dc.subjectEnfermedades de los Animales
dc.subjectAnimal Diseaseseng
dc.titleERAP1 and PDE8A are downregulated in cattle protected against bovine tuberculosises_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Biotecnologíaes_AR
dc.description.filFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.description.filFil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.description.filFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.subtypecientifico


Files in this item

Thumbnail

This item appears in the following Collection(s)

common

Show simple item record