Temas 

Temas

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    • Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles 

      Bigi, María Mercedes; Vazquez, Cristina Lourdes; Castelão, Ana Beatriz C.; Garcia, Elizabeth Andrea; Cataldi, Angel Adrian; Jackson, Mary; McNeil, Michael; Soria, Marcelo Abel; Zumarraga, Martin Jose; Cabruja, Matias; Gago, Gabriela; Blanco, Federico Carlos; Nishibe, Christiane; Almeida Junior, Nalvo Franco de; Araujo, Flabio Ribeiro de; Bigi, Fabiana (Elsevier, 2019-12)
      Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic ...

    • Campylobacter fetus releases S-layered and immunoreactive outer membrane vesicles = Campylobacter fetus secreta vesículas de membrana externa inmunorreactivas que conservan la capa S 

      Farace, Pablo; Cravero, Silvio Lorenzo Pedro; Taibo, Catalina Beatriz; Diodati, Julian Angel; Morsella, Claudia Graciela; Paolicchi, Fernando; Sabio Y Garcia, Julia Veronica; Gioffre, Andrea (Elsevier, 2021-08)
      The study of outer membrane vesicles (OMVs) became relevant because of their probable important role in the transfer of virulence factors to host cells. Campylobacter fetus is mainly a mammal pathogen whose virulence ...

    • Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution 

      Garcia Nuñez, Maria Soledad; Konig, Guido Alberto; Berinstein, Analia; Carrillo, Elisa Cristina (Elsevier, 2010-01)
      During the 2000–2001 epidemic of Foot-and-Mouth Disease Virus (FMDV) in Argentina, two FMDV serotype A viruses were identified among others. Since different pathogenic properties between these virus strains were noticed ...

    • Evaluation of a virulent strain of Mycobacterium avium subsp. Paratuberculosis used as a heat-killed vaccine 

      Colombatti Olivieri, Maria Alejandra; Moyano, Roberto Damian; Mon, Maria Laura; Gravisaco, María José; Alvarado Pinedo, María Fiorella; Delgado, Fernando Oscar; Hernández Pando, Rogelio; Alonso, Maria Natalia; Cuerda, Maria Ximena; Santangelo, María De La Paz; Romano, Maria Isabel (Elsevier, 2021-11)
      Bovine paratuberculosis is one of the most important chronic infectious diseases in livestock. This disease is difficult to control because of its inefficient management (test and cull strategy and inadequate biosecurity). ...

    • FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis 

      Mondino, Sonia; Vazquez, Cristina Lourdes; Cabruja, Matias; Sala, Claudia; Cazenave-Gassiot, Amaury; Blanco, Federico Carlos; Wenk, Markus R.; Bigi, Fabiana; Cole, Stewart T.; Gramajo, Hugo; Gago, Gabriela (Frontiers Media, 2020-10)
      Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world’s leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition ...

    • Genomic comparison of two strains of Mycobacterium avium subsp. paratuberculosis with contrasting pathogenic phenotype 

      Colombatti Olivieri, Maria Alejandra; Fresia, Pablo; Graña, Martín; Cuerda, Maria Ximena; Nagel, Ariel Gaston; Alvarado Pinedo, Maria Fiorella; Romano, Maria Isabel; Caimi, Karina Cynthia; Berná, Luisa; Santangelo, María De La Paz (Elsevier, 2023-01)
      In a previous study, we evaluated the degree of virulence of Mycobacterium avium subsp. paratuberculosis (Map) strains isolated from cattle in Argentina in a murine model. This assay allowed us to differentiate between ...

    • La genómica de las micobacterias 

      Viale, Mariana; Zumarraga, Martin Jose; Araujo, Flabio Ribeiro de; Zarraga, Ana Maria; Cataldi, Angel Adrian; Romano, Maria Isabel; Bigi, Fabiana (Office International des Epizooties, 2016)
      Las especies Mycobacterium bovis y Mycobacterium avium subsp. paratuberculosis son los agentes causales de la tuberculosis y la paratuberculosis en animales, respectivamente. Además, ambas micobacterias, pero fundamentalmente ...

    • Protection efficacy of Argentinian isolates of Mycobacterium avium subsp. paratuberculosis with different genotypes and virulence in a murine model 

      Colombatti Olivieri, Maria Alejandra; Moyano, Roberto Damian; Traveria, Gabriel Eduardo; Alvarado Pinedo, Maria Fiorella; Mon, Maria Laura; Gravisaco, María José; Delgado, Fernando Oscar; Santangelo, María De La Paz; Romano, Maria Isabel (Elsevier, 2018-12)
      Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include ...

    • Role of PhoPR in the response to stress of Mycobacterium bovis 

      Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Klepp, Laura Ines; Pazos, Adriana Alejandra; McNeil, Michael; Jackson, Mary; Bigi, Fabiana (Elsevier, 2021-02)
      PhoP is part of the two-component PhoPR system that regulates the expression of virulence genes of Mycobacteria. The goal of this work was to elucidate the role of PhoP in the mechanism that Mycobacterium bovis, the causative ...

    • Rv2577 of Mycobacterium tuberculosis is a virulence factor with dual phosphatase and phosphodiesterase functions 

      Forrellad, Marina Andrea; Blanco, Federico Carlos; Marrero Diaz De Vill, Rubén; Vazquez, Cristina Lourdes; Yaneff, Agustín; Garcia, Elizabeth Andrea; Gutierrez, Maximiliano Gabriel; Durán, Rosario; Villarino, Andrea; Bigi, Fabiana (Frontiers Media, 2020-10)
      Tuberculosis, a lung disease caused by Mycobacterium tuberculosis (Mtb), is one of the ten leading causes of death worldwide affecting mainly developing countries. Mtb can persist and survive inside infected cells through ...

    • Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress 

      Forrellad, Marina Andrea; Vazquez, Cristina Lourdes; Blanco, Federico Carlos; Klepp, Laura Ines; Garcia, Elizabeth Andrea; Rocha, Rosana Valeria; Villafañe, Luciana Maria; Bigi, María Mercedes; Gutierrez, Maximiliano Gabriel; Bigi, Fabiana (Taylor & Francis, 2019-12)
      In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this ...

    • Type VI secretion system in pathogenic escherichia coli: structure, role in virulence, and acquisition 

      Navarro-García, Fernando; Ruiz-Perez, Fernando; Cataldi, Angel Adrian; Larzabal, Mariano (Frontiers Media, 2019-08)
      Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through ...

    • Virulence factors of the Mycobacterium tuberculosis complex 

      Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffre, Andrea; Sabio y Garcia, Julia Veronica; Morbidoni, Hector R.; Santangelo, María De La Paz; Cataldi, Angel Adrian; Bigi, Fabiana (Taylor & Francis, 2013-01)
      The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and ...