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    • A transcriptional analysis of cattle immune cells reveals a central role of type 1 interferon in the In vitro innate immune response against Mycobacterium bovis 

      Blanco, Federico Carlos; Bigi, María Mercedes; Garcia, Elizabeth Andrea; Elola, María Teresa; Vazquez, Cristina Lourdes; Bigi, Fabiana (MDPI, 2023-09)
      Bovine tuberculosis is a chronic infectious disease primarily caused by Mycobacterium bovis, a bacterium that affects cattle and other mammals, including humans. Despite the availability of vast research about the immune ...

    • Assessing the impact of various tuberculin PPD brands on bovine tuberculosis diagnosis 

      Echeverria, Gustavo; Zumarraga, Martin Jose; Proaño‑Pérez, Freddy; Barceló Blasco, Francisco; Waard, Jacobus H. de (Springer Nature, 2024-03)
      Although several brands of tuberculin purified protein derivatives (PPDs) are available for diagnosing bovine tuberculosis (bTB), comparative studies to determine their diagnostic accuracy are infrequent. In Ecuador we ...

    • Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle 

      Klepp, Laura Ines; Colombatti Olivieri, Maria Alejandra; Moyano, Roberto Damian; Romano, Maria Isabel; Malovrh, Tadej; Ocepek, Matjaž; Blanco, Federico Carlos; Bigi, Fabiana (Sciendo, 2023-03)
      Introduction: Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis, respectively the causative agents of bovine tuberculosis (bTB) and bovine paratuberculosis (PTB), share a high number of antigenic proteins. ...

    • Mycobacterium bovis ESAT-6, CFP-10 and EspC antigens show high conservation among field isolates 

      Encinas, Micaela; Marfil, Maria Jimena; Garbaccio, Sergio Gabriel; Barandiaran, Soledad; Huertas, Pablo Sebastian; Morsella, Claudia Graciela; Macias, Analía; Magnano, Gabriel; Zapata, L.; Bigi, Fabiana; Cataldi, Angel Adrian; Paolicchi, Fernando; Zumarraga, Martin Jose; Eirin, Maria Emilia (Elsevier, 2018-07)
      ESAT-6, CFP-10 and EspC are virulence factors that have been extensively assayed for bovine and human tuberculosis diagnosis due their potent T-cell inducing activities. While polymorphisms of ESAT-6 and CFP-10 were analyzed, ...

    • The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis 

      Blanco, Federico Carlos; Garcia, Elizabeth Andrea; Aagaard, Claus; Bigi, Fabiana (Elsevier, 2021-05)
      H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis ...

    • Tuberculosis in wild pigs from Argentina 

      Barandiaran, Soledad; Marfil, Maria Jimena; La Sala, Luciano Francisco; Tammone, Agostina; Condori, Walter Ezequiel; Winter, Marina; Abate, Sergio; Rosas, Ana Carolina; Ponce, Loredana; Carpinetti, Bruno Nicolás; Serena, Maria Soledad; Lozano Calderon, Laura Camila; Zumarraga, Martin Jose (Springer, 2024)
      Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex (MTC) and non-tuberculous Mycobacteria (NTM), may infect wild and domestic mammals, including humans. Although cattle are the main hosts and spreaders ...