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Mostrando ítems 1-9 de 9
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An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenic Escherichia coli
Larzabal, Mariano; Baldoni, Hector A.; Suvire, Fernando D.; Curto, Lucrecia M.; Gomez, Gabriela E.; Marques Da Silva, Wanderson; Giudicessi, Silvana L.; Camperi, Silvia A.; Delfino, Jose M.; Cataldi, Angel Adrian; Enriz, Daniel (Wiley, 2019-03)Human pathogenic gram‐negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled‐coil domains present ... -
Clade 8 and clade 6 strains of Escherichia coli O157:H7 from cattle in Argentina have Hypervirulent-Like phenotypes
Amigo, Natalia; Mercado, Elsa Cristina; Bentancor, Adriana Beatriz; Singh, Pallavi; Vilte, Daniel Alejandro; Gerhardt, Elizabeth; Zotta, Elsa; Ibarra, Cristina Adriana; Manning, Shannon D.; Larzabal, Mariano; Cataldi, Angel Adrian (PLOS, 2015-06-01)The hemolytic uremic syndrome (HUS) whose main causative agent is enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a disease that mainly affects children under 5 years of age. Argentina is the country with the highest ... -
Early immune innate hallmarks and microbiome changes across the gut during Escherichia coli O157: H7 infection in cattle
Larzabal, Mariano; Marques Da Silva, Wanderson; Multani, Anmol; Vagnoni, Lucas Emilio; Moore, Prando Dadin; Marin, Maia Solange; Riviere, Nahuel Agustin; Delgado, Fernando Oscar; Vilte, Daniel Alejandro; Romero Victorica, Matias; Tao, Ma; Luo, Le Guan; Talia, Paola Mónica; Cataldi, Angel Adrian; Cobo, Eduardo Rubén (SpringerNature, 2020-12)The zoonotic enterohemorrhagic Escherichia coli (EHEC) O157: H7 bacterium causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS) in humans. Cattle are primary reservoirs and EHEC O157: H7; the bacteria ... -
Enterohemorrhagic Escherichia coli O157:H7 antigens produced in transgenic lettuce effective as an oral vaccine in mice
Su, Yun‑Lin; Larzabal, Mariano; Song, Huan; Cheng, Tianfang; Wang, Yufang; Smith, Libia Yael; Cataldi, Angel Adrian; Ow, David W. (Springer, 2023-10)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne pathogen where ruminant farm animals, mainly bovine, serve as reservoirs. Bovine vaccination has been used to prevent disease outbreaks, and the current ... -
Immunohistochemical detection of pro-inflammatory and anti-inflammatory cytokines in granulomas in cattle with natural Mycobacterium bovis infection
Canal, Ana María; Pezzone, Natalia; Cataldi, Angel Adrian; Zumarraga, Martin Jose; Larzabal, Mariano; Garbaccio, Sergio Gabriel; Fernández, Analía; Dominguez, Lucas; Aranaz, Alicia; Rodriguez-Bertos, Antonio (2017)Cellular immune response was evaluated in lymph nodes and lung with different granulomatous lesions from cattle naturally infected with Mycobacterium bovis. For this purpose, we assessed pro-inflammatory and anti-inflamm ... -
Novel Effector Protein EspY3 of Type III Secretion System from Enterohemorrhagic Escherichia coli Is Localized in Actin Pedestals
Larzabal, Mariano; Marques Da Silva, Wanderson; Riviere, Nahuel Agustín; Cataldi, Angel Adrian (MDPI AG, 2018)Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic Escherichia coli (EPEC) are attaching and effacing (A/E) pathogens, which translocate effector proteins to intestinal enterocytes through a type III secretion ... -
Overexpressed proteins in hypervirulent clade 8 and clade 6 strains of Escherichia coli O157:H7 compared to E. coli O157:H7 EDL933 clade 3 strain
Amigo, Natalia; Qi, Zhang; Amadio, Ariel; Qunjie, Zhang; Marques da Silva, Wanderson; Baiyuan, Cui; Zhongjian, Chen; Larzabal, Mariano; Cataldi, Angel Adrian; Jinlong, Bei (2016)Escherichia coli O157:H7 is responsible for severe diarrhea and hemolytic uremic syndrome (HUS), and predominantly affects children under 5 years. The major virulence traits are Shiga toxins, necessary to develop HUS and ... -
The role of glucose in the pathology of EHEC O157: H7
Marques Da Silva, Wanderson; Taibo, Catalina Beatriz; Sabio Y Garcia, Julia Veronica; Larzabal, Mariano; Cataldi, Angel Adrian (Cambridge University Press, 2020-04)The pathogen enterohemorrhagic Escherichia coli (EHEC) O157: H7 is responsible for hemorrhagic colitis and hemolytic uremic syndrome in humans [1]. During the colonization process in the gastrointestinal tract, EHEC needs ... -
Type VI secretion system in pathogenic escherichia coli: structure, role in virulence, and acquisition
Navarro-García, Fernando; Ruiz-Perez, Fernando; Cataldi, Angel Adrian; Larzabal, Mariano (Frontiers Media, 2019-08)Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through ...