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Resumen
Anaplasma marginale is an intraerythrocytic vector-borne infectious agent of cattle. Immunization with the current vaccine, based on parasitized erythrocytes with live Anaplasma centrale, shows some constraints and confers partial protection, suggesting the feasibility for the development of new generation of vaccines. The aim of the present study was to assess the effect of sequential immunization of BALB/c mice, with herpesvirus amplicon vector-based
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dc.contributor.author | Palacios, Carlos Adolfo | |
dc.contributor.author | Torioni, Susana Marta | |
dc.contributor.author | Mattion, Nora Marta | |
dc.date.accessioned | 2018-08-09T12:53:44Z | |
dc.date.available | 2018-08-09T12:53:44Z | |
dc.date.issued | 2014-12 | |
dc.identifier.issn | 0034-5288 | |
dc.identifier.other | https://doi.org/10.1016/j.rvsc.2014.10.005 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S003452881400294X | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/3028 | |
dc.description.abstract | Anaplasma marginale is an intraerythrocytic vector-borne infectious agent of cattle. Immunization with the current vaccine, based on parasitized erythrocytes with live Anaplasma centrale, shows some constraints and confers partial protection, suggesting the feasibility for the development of new generation of vaccines. The aim of the present study was to assess the effect of sequential immunization of BALB/c mice, with herpesvirus amplicon vector-based vaccines combined with protein-based vaccines, on the quality of the immune response against the major surface protein 5 of A. marginale. The highest antibody titers against MSP5 were elicited in mice that received two doses of adjuvanted recombinant protein (p < 0.0001). Mice treated with a heterologous prime-boost strategy generated sustained antibody titers at least up to 200 days, and a higher specific cellular response. The results presented here showed that sequential immunization with HSV-based vectors and purified antigen enhances the quality of the immune response against A. marginale. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.source | Research in Veterinary Science 97 (3) : 514-520 (December 2014) | es_AR |
dc.subject | Anaplasma Marginale | es_AR |
dc.subject | Respuesta Inmunológica | es_AR |
dc.subject | Immune Response | eng |
dc.subject | Proteínas Recombinantes | es_AR |
dc.subject | Recombinant Proteins | eng |
dc.subject | Vectores | es_AR |
dc.subject | Vectors | eng |
dc.subject | Ganado Bovino | es_AR |
dc.subject | Cattle | eng |
dc.title | Evaluation of the immune response to Anaplasma marginale MSP5 protein using a HSV-1 amplicon vector system or recombinant protein | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.description.origen | EEA Rafaela | es_AR |
dc.description.fil | Fil: Palacios, Carlos Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencias y Tecnología "Dr. Cesar Milstein". Centro de Virología Animal; Argentina | es_AR |
dc.description.fil | Fil: Torioni, Susana Marta. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina | es_AR |
dc.description.fil | Fil: Mattion, Nora Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencias y Tecnología "Dr. Cesar Milstein". Centro de Virología Animal; Argentina | es_AR |
dc.subtype | cientifico |
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