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Abstract
The prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in [ver mas...]
dc.contributor.authorNani, Juan Pablo
dc.contributor.authorRaschia, Maria Agustina
dc.contributor.authorCarignano, Hugo
dc.contributor.authorPoli, Mario Andres
dc.contributor.authorCalvinho, Luis Fernando
dc.contributor.authorAmadio, Ariel
dc.date.accessioned2018-07-19T13:01:28Z
dc.date.available2018-07-19T13:01:28Z
dc.date.issued2015-11
dc.identifier.issn1234-1983
dc.identifier.issn2190-3883
dc.identifier.otherhttps://doi.org/10.1007/s13353-015-0278-5
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs13353-015-0278-5
dc.identifier.urihttp://hdl.handle.net/20.500.12123/2823
dc.description.abstractThe prevention and control of bovine mastitis by enhancing natural defenses in animals is important to improve the quality of dairy products. Mastitis resistance is a complex trait which depends on genetic components, as well as environmental and physiological factors. The limitations of classical control measures have led to the search for alternative approaches to minimize the use of antibiotics by selecting naturally resistant animals. Polymorphisms in genes associated with the innate immune system are strong candidates to be evaluated as genetic markers. In this work, we evaluated a set of single nucleotide polymorphisms (SNPs) in candidate genes for health and production traits, and determined their association with the somatic cell score (SCS) as an indicator of mastitis in Argentinean dairy cattle. We evaluated 941 cows: Holstein (n = 677) and Holstein × Jersey (n = 264) crossbred, daughters from 22 bulls from 14 dairy farms located in the central dairy area of Argentina. Two of the 21 successfully genotyped markers were found to be significantly associated (p < 0.05) with the SCS: GHR_140 and OPN_8514C-T. The heterozygote genotype for GHR_140 showed a favorable effect in reducing the SCS. On the other hand, heterozygote genotypes for OPN8514C-T caused an increase in the SCS; moreover, combined genotypes for OPN SNPs showed an even larger effect. These findings can contribute to the design of effective marker-assisted selection programs.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceJournal of Applied Genetics 56 (4) : 505–513 (November 2015)es_AR
dc.subjectGanado de Lechees_AR
dc.subjectDairy Cattleeng
dc.subjectControl de Enfermedadeses_AR
dc.subjectDisease Controleng
dc.subjectEnfermedades de los Animaleses_AR
dc.subjectAnimal Diseaseseng
dc.subjectMastítis Bovinaes_AR
dc.subjectBovine Mastitiseng
dc.subjectGeneses_AR
dc.subjectCélulas Somáticases_AR
dc.subjectSomatic Cellseng
dc.subject.otherArgentinaes_AR
dc.titleSingle nucleotide polymorphisms in candidate genes and their relation with somatic cell scores in Argentinean dairy cattlees_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEEA Rafaelaes_AR
dc.description.filFil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentinaes_AR
dc.description.filFil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentinaes_AR
dc.description.filFil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentinaes_AR
dc.description.filFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentinaes_AR
dc.description.filFil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentinaes_AR
dc.description.filFil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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