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Resumen
The tobacco mosaic virus (TMV) is one of the most studied viruses. It is frequently used as a model in the research of virus-host interactions. The interest in understanding the mechanism of its proliferation stems basically from the field of agriculture, due to the detrimental effect this virus has on several crops. In addition to this direct application, virus-mediated protein expression systems, which are well established for the synthesis of foreign [ver mas...]
dc.contributor.authorMerchuk, Jose C.
dc.contributor.authorSánchez Mirón, Asterio
dc.contributor.authorAsurmendi, Sebastian
dc.contributor.authorShacham, Mordechai
dc.date.accessioned2018-04-04T13:07:50Z
dc.date.available2018-04-04T13:07:50Z
dc.date.issued2016
dc.identifier.issn1998-4510
dc.identifier.urihttp://hdl.handle.net/20.500.12123/2161
dc.identifier.urihttp://www.naun.org/main/NAUN/bio/2016/a462010-066.pdf
dc.description.abstractThe tobacco mosaic virus (TMV) is one of the most studied viruses. It is frequently used as a model in the research of virus-host interactions. The interest in understanding the mechanism of its proliferation stems basically from the field of agriculture, due to the detrimental effect this virus has on several crops. In addition to this direct application, virus-mediated protein expression systems, which are well established for the synthesis of foreign proteins in animal cell cultures, are now being applied to plants and plant cells by means of plant viral vectors. The use of transformed roots for the propagation of viral vectors has also been proposed. This work presents a mechanistic model describing the transient process of TMV multiplication in a protoplast (a wall-deprived cell). It aims to be a mathematical tool able to simulate the transient behavior of the main molecular pools taking part in the process, which will be useful for exploring, understanding and predicting the dynamics of a host-virus system. The variables considered are the pools of the main molecules taking part in the viral replication process. The basic balance equations for the cellular pools are presented and a satisfactory fit of the model to the experimental data is shown. The presented model is a necessary step toward the formulation of a basic mechanistic model for the systemic propagation of the virus in a plant tissue. It may be extended in many directions as to the optimization of a system for the production of a foreign protein, to the simulation of manipulation of the virus-cell interaction by external factors, to the mechanism of gene silencing or to the prediction of co-infection dynamics.es_AR
dc.formatapplication/pdfeng
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/openAccesseng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceInternational journal of biology and biomedical engineering 10 : 202-210. (2016)eng
dc.subjectVirus de las Plantases_AR
dc.subjectNicotiana Tabacumes_AR
dc.subjectTabacoes_AR
dc.subjectModelos de Simulaciónes_AR
dc.subjectVirosises_AR
dc.subjectViroseseng
dc.subjectViruseseng
dc.subjectSimulation Modelseng
dc.subjectTobaccoeng
dc.subjectPlant Viruseseng
dc.subject.otherVirus del Mosaico del Tabacoes_AR
dc.subject.otherVirus Propagationeng
dc.titleModeling tobacco mosaic virus proliferation in protoplastseng
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.filFil: Merchuk, Jose C. Ben-Gurion University of the Negev; Israeles_AR
dc.description.filFil: Sánchez-Mirón, Asterio. Universidad de Almería; Españaes_AR
dc.description.filFil: Asurmendi, Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentinaes_AR
dc.description.filFil: Shacham, Mordechai. Ben-Gurion University of the Negev; Israeles_AR
dc.subtypecientifico


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