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Interleukin 22 is a member of the interleukin-10 superfamily of cytokines. This protein has a dual role as an inflammatory and anti-inflammatory molecule dependent on the context. IL-22 is produced mainly by immune cells and seems to have non-hematopoietic cells as its target. In this work, we report the production of bovine IL-22 for the first time in a semi-stable expression system in mammalian cells. We showed that this recombinant IL-22 possesses [ver mas...]
dc.contributor.authorKlepp, Laura Ines
dc.contributor.authorBigi, María Mercedes
dc.contributor.authorVillafañe, Luciana María
dc.contributor.authorBlanco, Federico Carlos
dc.contributor.authorMalinge, Pauline
dc.contributor.authorBigi, Fabiana
dc.date.accessioned2025-02-26T13:39:07Z
dc.date.available2025-02-26T13:39:07Z
dc.date.issued2025-01
dc.identifier.issn0165-2427
dc.identifier.otherhttps://doi.org/10.1016/j.vetimm.2024.110863
dc.identifier.urihttp://hdl.handle.net/20.500.12123/21474
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0165242724001491
dc.description.abstractInterleukin 22 is a member of the interleukin-10 superfamily of cytokines. This protein has a dual role as an inflammatory and anti-inflammatory molecule dependent on the context. IL-22 is produced mainly by immune cells and seems to have non-hematopoietic cells as its target. In this work, we report the production of bovine IL-22 for the first time in a semi-stable expression system in mammalian cells. We showed that this recombinant IL-22 possesses biological activity in bovine macrophages infected with Mycobacterium bovis and is easy to produce in large quantities. Given its role in the defence against infections, the IL-22 produced in this work has potential applications in scientific research as well as in immunotherapy to treat diseases in cattle.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.relationinfo:eu-repograntAgreement/INTA/2023-PD-L06-I116, Implementación de tecnologías y nuevas estrategias preventivas y terapéuticas para el desarrollo sustentable y eficiente de la producción animal en el marco de Una Saludes_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/es_AR
dc.sourceVeterinary Immunology and Immunopathology 279 : 110863 (January 2025)es_AR
dc.subjectCattleeng
dc.subjectGanado Bovinoes_AR
dc.subjectMycobacterium boviseng
dc.subjectCytokineseng
dc.subjectCitoquinaes_AR
dc.subjectImmunotherapyeng
dc.subjectInmunoterapiaes_AR
dc.subject.otherMammalian Cellseng
dc.subject.otherCélulas de Mamíferoses_AR
dc.titleProduction of functional bovine IL-22 in a mammalian episomal expression systemes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)es_AR
dc.description.origenInstituto de Biotecnologíaes_AR
dc.description.filFil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Klepp, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Bigi, María Mercedes. Universidad de Buenos Aires. Facultad de Medicina; Argentinaes_AR
dc.description.filFil: Villafañe, Luciana María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Villafañe, Luciana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Malinge, Pauline. Novimmune SA. Light Chain Bioscience; Suizaes_AR
dc.description.filFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Bigi, Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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