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Background: Latent tuberculosis has been associated with the persistence of dormant Mycobacterium tuberculosis in the organism of infected individuals, who are reservoirs of the bacilli and the source for spreading the disease in the community. New active anti-TB drugs exerting their metabolic action at different stages and on latent/dormant bacilli are urgently required to avoid endogenous reactivations and to be part of treatments of multi- and [ver mas...]
dc.contributor.authorImperiale, Belen Rocio
dc.contributor.authorCataldi, Angel Adrian
dc.contributor.authorMorcillo, Nora
dc.date.accessioned2018-03-05T15:41:50Z
dc.date.available2018-03-05T15:41:50Z
dc.date.issued2017-12
dc.identifier.otherhttp://dx.doi.org/10.1016/j.ram.2017.02.008
dc.identifier.urihttp://hdl.handle.net/20.500.12123/1961
dc.identifier.urihttp://www.elsevier.es/en-revista-revista-argentina-microbiologia-372-resumen-in-vitro-anti-tuberculosis-activity-azole-S0325754117300895
dc.description.abstractBackground: Latent tuberculosis has been associated with the persistence of dormant Mycobacterium tuberculosis in the organism of infected individuals, who are reservoirs of the bacilli and the source for spreading the disease in the community. New active anti-TB drugs exerting their metabolic action at different stages and on latent/dormant bacilli are urgently required to avoid endogenous reactivations and to be part of treatments of multi- and extensively-drug resistant tuberculosis (M/XDR-TB). It was previously reported that azole drugs are active against M. tuberculosis. For that reason, the aims of this study were to determine the in vitro activity of azole drugs, imidazole (clotrimazole, CLO and econazole, ECO) and nitroimidazole (metronidazole, MZ and ipronidazole, IPZ), against a collection of MDR M. tuberculosis clinical isolates; and to analyze their potential use in both the LTB and the active forms of M/XDR-TB treatments. Methods: A total of 55 MDR M. tuberculosis isolates and H37Rv were included. MZ and IPZ activity against M. tuberculosis isolates were tested using anaerobic culture conditions. The activity of ECO and CLO was measured by the minimal inhibitory concentration (MIC) using a microdilution colorimetric method.eng
dc.formatapplication/pdf
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista Argentina de Microbiología 49 (4) : 332-338 (October - December 2017)
dc.subjectMycobacterium
dc.subjectResistencia a Medicamentos
dc.subjectDrug Resistanceeng
dc.subjectAzoles
dc.subjectMycobacterium Tuberculosis
dc.subjectImidazoles
dc.subjectExperimentación in Vitro
dc.subjectIn Vitro Experimentationeng
dc.titleIn vitro anti-tuberculosis activity of azole drugs against Mycobacterium tuberculosis clinical isolates
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.description.origenInst. de Biotecnología
dc.gic155505
dc.description.filFil: Imperiale, Belen Rocio. Hospital Dr. Antonio A. Cetrángolo. Laboratorio de Referencia del Programa de Control de la Tuberculosis de la provincia de Buenos Aires; Argentina
dc.description.filFil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
dc.description.filFil: Morcillo, Nora. Hospital Dr. Antonio A. Cetrángolo. Laboratorio de Referencia del Programa de Control de la Tuberculosis de la provincia de Buenos Aires; Argentina
dc.subtypecientifico


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