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Background: Latent tuberculosis has been associated with the persistence of dormant Mycobacterium tuberculosis in the organism of infected individuals, who are reservoirs of the bacilli and the source for spreading the disease in the community. New active anti-TB drugs exerting their metabolic action at different stages and on latent/dormant bacilli are urgently required to avoid endogenous reactivations and to be part of treatments of multi- and
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dc.contributor.author | Imperiale, Belen Rocio | |
dc.contributor.author | Cataldi, Angel Adrian | |
dc.contributor.author | Morcillo, Nora | |
dc.date.accessioned | 2018-03-05T15:41:50Z | |
dc.date.available | 2018-03-05T15:41:50Z | |
dc.date.issued | 2017-12 | |
dc.identifier.other | http://dx.doi.org/10.1016/j.ram.2017.02.008 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/1961 | |
dc.identifier.uri | http://www.elsevier.es/en-revista-revista-argentina-microbiologia-372-resumen-in-vitro-anti-tuberculosis-activity-azole-S0325754117300895 | |
dc.description.abstract | Background: Latent tuberculosis has been associated with the persistence of dormant Mycobacterium tuberculosis in the organism of infected individuals, who are reservoirs of the bacilli and the source for spreading the disease in the community. New active anti-TB drugs exerting their metabolic action at different stages and on latent/dormant bacilli are urgently required to avoid endogenous reactivations and to be part of treatments of multi- and extensively-drug resistant tuberculosis (M/XDR-TB). It was previously reported that azole drugs are active against M. tuberculosis. For that reason, the aims of this study were to determine the in vitro activity of azole drugs, imidazole (clotrimazole, CLO and econazole, ECO) and nitroimidazole (metronidazole, MZ and ipronidazole, IPZ), against a collection of MDR M. tuberculosis clinical isolates; and to analyze their potential use in both the LTB and the active forms of M/XDR-TB treatments. Methods: A total of 55 MDR M. tuberculosis isolates and H37Rv were included. MZ and IPZ activity against M. tuberculosis isolates were tested using anaerobic culture conditions. The activity of ECO and CLO was measured by the minimal inhibitory concentration (MIC) using a microdilution colorimetric method. | eng |
dc.format | application/pdf | |
dc.language.iso | eng | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Revista Argentina de Microbiología 49 (4) : 332-338 (October - December 2017) | |
dc.subject | Mycobacterium | |
dc.subject | Resistencia a Medicamentos | |
dc.subject | Drug Resistance | eng |
dc.subject | Azoles | |
dc.subject | Mycobacterium Tuberculosis | |
dc.subject | Imidazoles | |
dc.subject | Experimentación in Vitro | |
dc.subject | In Vitro Experimentation | eng |
dc.title | In vitro anti-tuberculosis activity of azole drugs against Mycobacterium tuberculosis clinical isolates | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.origen | Inst. de Biotecnología | |
dc.gic | 155505 | |
dc.description.fil | Fil: Imperiale, Belen Rocio. Hospital Dr. Antonio A. Cetrángolo. Laboratorio de Referencia del Programa de Control de la Tuberculosis de la provincia de Buenos Aires; Argentina | |
dc.description.fil | Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina | |
dc.description.fil | Fil: Morcillo, Nora. Hospital Dr. Antonio A. Cetrángolo. Laboratorio de Referencia del Programa de Control de la Tuberculosis de la provincia de Buenos Aires; Argentina | |
dc.subtype | cientifico |
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