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Abstract
The melanocortin 1-receptor (MC1R) and the agouti signaling protein (ASIP) are the major genes controlling the type and location of pigments produced in mammals. In recent years, polymorphisms in these genes have been associated with coat color variation in a number of species. Llamas (Lama glama) are characterized by a great diversity of coat colors. However, the genetic basis of coat color determination is still unknown. Here, we sequenced the MC1R and [ver mas...]
dc.contributor.authorDaverio, Maria Silvana
dc.contributor.authorRigalt, Francisco Antonio
dc.contributor.authorRomero, Sandra Raquel
dc.contributor.authorVidal Rioja, Lidia
dc.contributor.authorDi Rocco, Florencia
dc.date.accessioned2018-03-05T14:04:52Z
dc.date.available2018-03-05T14:04:52Z
dc.date.issued2016-11
dc.identifier.issn0921-4488
dc.identifier.otherhttps://doi.org/10.1016/j.smallrumres.2016.08.003
dc.identifier.urihttp://hdl.handle.net/20.500.12123/1956
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0921448816301973
dc.description.abstractThe melanocortin 1-receptor (MC1R) and the agouti signaling protein (ASIP) are the major genes controlling the type and location of pigments produced in mammals. In recent years, polymorphisms in these genes have been associated with coat color variation in a number of species. Llamas (Lama glama) are characterized by a great diversity of coat colors. However, the genetic basis of coat color determination is still unknown. Here, we sequenced the MC1R and ASIP genes in llamas and studied the association between the polymorphisms identified and the coat color. Sequence analysis revealed ten nonsynonymous single nucleotide polymorphisms in the MC1R gene. Three main haplotypes were identified, none of which were completely associated to a particular color phenotype. However, significant association was detected between the MC1R*1 haplotype and the presence of pigmented coat (P < 0.0001). Compared to the wild allele, MC1R*1 carried two amino acid substitutions, p.G126S and p.V87 M. This last replacement occurs at a highly conserved residue among mammals and the same substitution has been previously associated to melanic phenotypes in avian species. Furthermore, two polymorphisms in ASIP exon 4, a 57 bp deletion (c.325_381del) and c.292C > T that are both predicted to have a deleterious effect on the protein, were found in homozygous state or combined in most llamas with eumelanic coat.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceSmall ruminant research 144 : 83-89. (November 2016)es_AR
dc.subjectLlamaes_AR
dc.subjectLlamaseng
dc.subjectFenotiposes_AR
dc.subjectPhenotypeseng
dc.subjectPolimorfismoes_AR
dc.subjectPolymorphismeng
dc.subjectGeneses_AR
dc.subjectGenéticaes_AR
dc.subjectGeneticseng
dc.titlePolymorphisms in MC1R and ASIP genes and their association with coat color phenotypes in llamas (Lama glama)es_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEEA Catamarcaes_AR
dc.description.filFil: Daverio, Maria Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentinaes_AR
dc.description.filFil: Rigalt, Francisco Antonio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; Argentinaes_AR
dc.description.filFil: Romero, Sandra Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Abra Pampa; Argentinaes_AR
dc.description.filFil: Vidal Rioja, Lidia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentinaes_AR
dc.description.filFil: Di Rocco, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentinaes_AR
dc.subtypecientifico


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