Now showing items 1-20 of 275

    • FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis 

      Mondino, Sonia; Vazquez, Cristina Lourdes; Cabruja, Matias; Sala, Claudia; Cazenave-Gassiot, Amaury; Blanco, Federico Carlos; Wenk, Markus R.; Bigi, Fabiana; Cole, Stewart T.; Gramajo, Hugo; Gago, Gabriela (Frontiers Media, 2020-10)
      Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is the world’s leading cause of death from an infectious disease. One of the main features of this pathogen is the complex and dynamic lipid composition ...
    • Identification and characterization of a Babesia bigemina thrombospondin-related superfamily member, TRAP-1 : a novel antigen containing neutralizing epitopes involved in merozoite invasion 

      Montenegro, Valeria Noely; Paoletta, Martina; Jaramillo Ortiz, Jose; Suarez, Carlos Esteban; Wilkowsky, Silvina Elizabeth (BioMed Central, 2020-12)
      Background: Thrombospondin-related anonymous protein (TRAP) has been described as a potential vaccine candidate for several diseases caused by apicomplexan parasites. However, this protein and members of this family have ...
    • Rv2577 of Mycobacterium tuberculosis is a virulence factor with dual phosphatase and phosphodiesterase functions 

      Forrellad, Marina Andrea; Blanco, Federico Carlos; Marrero Diaz De Vill, Rubén; Vazquez, Cristina Lourdes; Yaneff, Agustín; Garcia, Elizabeth Andrea; Gutierrez, Maximiliano Gabriel; Durán, Rosario; Villarino, Andrea; Bigi, Fabiana (Frontiers Media, 2020-10)
      Tuberculosis, a lung disease caused by Mycobacterium tuberculosis (Mtb), is one of the ten leading causes of death worldwide affecting mainly developing countries. Mtb can persist and survive inside infected cells through ...
    • Virus infection elevates transcriptional activity of miR164a promoter in plants 

      Bazzini, Ariel Alejandro; Almasia, Natalia Ines; Manacorda, Carlos Augusto; Mongelli, Vanesa Claudia; Conti, Gabriela; Maroniche, Guillermo Andrés; Rodriguez, Maria Cecilia; Distefano, Ana Julia; Hopp, Horacio Esteban; Del Vas, Mariana; Asurmendi, Sebastian (BioMed Central, 2009-12)
      Background: Micro RNAs (miRs) constitute a large group of endogenous small RNAs that have crucial roles in many important plant functions. Virus infection and transgenic expression of viral proteins alter accumulation and ...
    • Overexpression of snakin-1 gene enhances resistance to Rhizoctonia solani and Erwinia carotovora in transgenic potato plants 

      Almasia, Natalia Ines; Bazzini, Ariel Alejandro; Hopp, Horacio Esteban; Vazquez Rovere, Cecilia (Wiley-Blackwell, 2008-05)
      Snakin‐1 (SN1), a cysteine‐rich peptide with broad‐spectrum antimicrobial activity in vitro, was evaluated for its ability to confer resistance to pathogens in transgenic potatoes. Genetic variants of this gene were cloned ...
    • Isolation and characterization of the tissue and development-specific potato snakin-1 promoter inducible by temperature and wounding 

      Almasia, Natalia Ines; Nahirñak, Vanesa; Hopp, Horacio Esteban; Vazquez Rovere, Cecilia (Pontificia Universidad Catolica de Valparaiso, 2010-09)
      Snakin-1 (StSN1) is a broad-spectrum antimicrobial peptide isolated from Solanum tuberosum. Homologous proteins have been identified in a wide range of species but there is no apparent consensus in the roles they play. A ...
    • IL-12 DNA Displays efficient adjuvant effects improving immunogenicity of Ag85A in DNA prime/MVA boost immunizations 

      Morelli, María Paula; Del Medico Zajac, Maria Paula; Pellegrini, Joaquín Miguel; Amiano, Nicolás Oscar; Tateosian, Nancy Liliana; Calamante, Gabriela; Gherardi, Maria Magdalena; García, Verónica Edith (Frontiers Media, 2020-09)
      Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, ...
    • Molecular characterization of Mycobacterium bovis infection in cattle and buffalo in Amazon Region, Brazil 

      Carneiro, Paulo A.M.; Pasquatti, Taynara N.; Takatani, Haruo; Zumarraga, Martin Jose; Marfil, Maria Jimena; Barnard, Christian; Fitzgerald, Scott D.; Abramovitch, Robert B.; Araujo, Flabio Ribeiro de; Kaneene, John B. (Wiley, 2020-02)
      The aim of this study was to characterize Mycobacterium bovis from cattle and buffalo tissue samples, from two Brazilian states, and to analyse their genetic diversity by spoligotyping. Tissue samples from tuberculosis ...
    • Transgenic citrange troyer rootstocks overexpressing antimicrobial potato snakin-1 show reduced citrus canker disease symptoms 

      Conti, Gabriela; Gardella, Victoria; Vandecaveye, Melina Antonella; Gomez, Claudio Andres; Joris, Giovanna Lujan; Hauteville, Claudia; Burdyn, Lourdes; Almasia, Natalia Ines; Nahirñak, Vanesa; Vazquez Rovere, Cecilia; Gochez, Alberto Martin; Furman, Nicolas; Lezcano, Cecilia Carolina; Kobayashi, Ken; García, María Laura; Canteros, Blanca Isabel; Hopp, Horacio Esteban; Reyes, Carina Andrea (Elsevier, 2020-12)
      Citrus canker is a major disease caused by Xanthomonas citri pv. citri. Snakin-1 is an antimicrobial peptide, which was previously shown to be effective against different bacterial and fungal diseases in potato, wheat and ...
    • Potato snakin‑1: an antimicrobial player of the trade‑off between host defense and development 

      Almasia, Natalia Ines; Nahirñak, Vanesa; Hopp, Horacio Esteban; Vazquez Rovere, Cecilia (Springer, 2020-07)
      Snakin-1 (SN1) from potato is a cysteine-rich antimicrobial peptide with high evolutionary conservation. It has 63 amino acid residues, 12 of which are cysteines capable of forming six disulfide bonds. SN1 localizes in the ...
    • Detection of Mycobacterium bovis–infected dairy herds using PCR in bulk tank milk samples 

      Zumarraga, Martin Jose; Soutullo, Adriana; Garcia, Maria Ines; Marini, M. Rocío; Abdala, Alejandro Ariel; Tarabla, Hector Dante; Echaide, Susana T. de; Lopez, Marcela; Zervini, Elsa; Canal, Ana María; Cataldi, Angel Adrian (Mary Ann Liebert Inc., 2012-02)
      Bovine tuberculosis (bTB) is a chronic and zoonotic disease due to Mycobacterium bovis. The tuberculosis eradication campaign carried out in Argentina has considerably improved the health situation of the herds. Here we ...
    • Understanding the relationship between Mycobacterium bovis spoligotypes from cattle in Latin American Countries 

      Zumarraga, Martin Jose; Arriaga, Camila; Barandiaran, Soledad; Cobos-Marín, Laura; de Waard, Jacobus; Estrada-Garcia, Iris; Figueiredo, Telma; Figueroa, Alvaro; Gimenez, Francisco; Gomes, Harrison M.; Gonzalez-y-Merchand, Jorge A.; Macías, Analía; Milián-Suazo, Feliciano; Rodríguez, Cesar Alejandro Rosales; Santillán, Marco Antonio; Suffys, Philip Noel; Trangoni, Marcos David; Zarraga, Ana Maria; Cataldi, Angel Adrian (Elsevier, 2013-02)
      Spoligotyping is the most frequently used method for genotyping isolates of Mycobacterium bovis worldwide. In the current work, we compared spoligotypes from 1684 M. bovis isolates from Argentina (816), Brazil (412), Chile ...
    • La genómica de las micobacterias 

      Viale, Mariana; Zumarraga, Martin Jose; Araujo, Flabio Ribeiro de; Zarraga, Ana Maria; Cataldi, Angel Adrian; Romano, Maria Isabel; Bigi, Fabiana (Office International des Epizooties, 2016)
      Las especies Mycobacterium bovis y Mycobacterium avium subsp. paratuberculosis son los agentes causales de la tuberculosis y la paratuberculosis en animales, respectivamente. Además, ambas micobacterias, pero fundamentalmente ...
    • LAMP technology: Rapid identification of Brucella and Mycobacterium avium subsp. paratuberculosis 

      Trangoni, Marcos David; Gioffre, Andrea; Ceron Cucchi, Maria Esperanza; Caimi, Karina Cynthia; Ruybal, Paula; Zumarraga, Martin Jose; Cravero, Silvio Lorenzo Pedro (Sociedade Brasileira de Microbiologia, 2015-06)
      In this study, we developed new sets of primers to detect Brucella spp. and M. avium subsp. paratuberculosis (MAP) through isothermal amplification. We selected a previously well-characterized target gene, bscp31, specific ...
    • Use of touch-down polymerase chain reaction to enhance the sensitivity of Mycobacterium bovis detection 

      Zumarraga, Martin Jose; Meikle, Virginia; Bernardelli, Amelia; Abdala, Alejandro Ariel; Tarabla, Hector Dante; Romano, Maria Isabel; Cataldi, Angel Adrian (Sage Publications, 2005-05)
      The confirmatory diagnosis of Mycobacterium bovis (M. bovis) in animal samples is carried out by culture in Stonebrink media. However, culture is very slow because of the extremely long duplication time of the bacillus and ...
    • Mycobacterium bovis infection in a horse with granulomatous enterocolitis 

      Sarradell, Javier E.; Alvarez, Julio; Biscia, Mariana; Zumarraga, Martin Jose; Wunschmann, Arno; Armien, Aníbal G.; Perez, Andrés M. (Sage Publications, 2015-03)
      A 2-year-old dappled Percheron horse had a wasting condition that did not respond to antibiotic treatments and ultimately resulted in death. Thickening of the wall of the large colon and enlargement of the mesenteric lymph ...
    • Mycobacterium intracellulare infection in a capybara (Hydrochoerus hydrochaeris) 

      Pezzone, Natalia; Eberhardt, Ayelén; Fernandez, Analía; Garbaccio, Sergio Gabriel; Zumarraga, Martin Jose; Gioffre, Andrea; Magni, Carolina; Beldomenico, Pablo Martín; Marini, M. Rocío; Canal, Ana María (American Association of Zoo Veterinarians, 2013-12)
      This report describes the first case of Mycobacterium intracellulare infection with typical granulomatous lesions of mycobacteriosis in a capybara (Hydrochoerus hydrochaeris). The individual was a captive-bred young female, ...
    • Patterns and processes of mycobacterium bovis evolution revealed by phylogenomic analyses 

      Patané, José S. L.; Martins Jr, Joaquim; Castelão, Ana Beatriz C.; Nishibe, Christiane; Montera, Luciana; Bigi, Fabiana; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Fonseca Junior, Antônio; Roxo, Eliana; Osório, Ana Luiza Alves Rosa; Jorge, Klaudia dos Santos Goncalves; Thacker, Tyler C.; Almeida, Nalvo F.; Araujo, Flabio Ribeiro de; Setubal, Joâo C. (Oxford University Press, 2017-03)
      Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from the United Kingdom, South ...
    • Draft genome sequence of Mycobacterium bovis 04-303, a highly virulent strain from Argentina 

      Nishibe, Christiane; Canevari Castelão, Ana Beatriz; Dalla Costa, Ricardo; Pinto, Beatriz Jeronimo; Varuzza, Leonardo; Cataldi, Angel Adrian; Bernardelli, Amelia; Bigi, Fabiana; Blanco, Federico Carlos; Zumarraga, Martin Jose; Almeida, Nalvo Franco; Araujo, Flabio Ribeiro de (American Society for Microbiology, 2013-11)
      Mycobacterium bovis strain 04-303 was isolated from a wild boar living in a free-ranging field in Argentina. This work reports the draft genome sequence of this highly virulent strain and the genomic comparison of its major ...
    • Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts 

      Morcillo, Nora; Imperiale, Belen Rocio; Di Giulio, Angela Beatríz; Zumarraga, Martin Jose; Takif, Howard; Cataldi, Angel Adrian (Elsevier, 2014-12)
      There has been an on-going debate on whether the development of drug resistance in Mycobacterium tuberculosis reduces its relative fitness and its ability to cause disease. The aim of this study was to explore this ...