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    xmlui.general.dspace_homeCentros e Institutos de InvestigaciónCICVyA. Centro de Investigación en Ciencias Veterinarias y AgronómicasInstituto de Biotecnologíaxmlui.ArtifactBrowser.ConfigurableBrowse.trail.item.titleInstituto de Biotecnología
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    • 2° Simposio de Ciencias Agrarias del INTA. Un futuro sostenible: Integrando ciencia y producción en la agronomía moderna. Libro de resúmenes 

      Simposio de Ciencias Agrarias del INTA (2 : 2024 : Córdoba) (Instituto Nacional de Tecnología Agropecuaria (INTA), 2024)
      El eje central del Simposio es “Un Futuro Sostenible: Integrando Ciencia y Producción en la Agronomía Moderna”. Esta temática no solo nos invita a pensar en la producción como una actividad rentable y eficiente, sino ...
    • A beginner’s guide for FMDV quasispecies analysis: sub-consensus variant detection and haplotype reconstruction using next-generation sequencing 

      Cacciabue, Marco Polo; Curra, Anabella Paola; Carrillo, Elisa Cristina; Konig, Guido Alberto; Gismondi, Maria Ines (Oxford Academic Press, 2020-09)
      Deep sequencing of viral genomes is a powerful tool to study RNA virus complexity. However, the analysis of next-generation sequencing data might be challenging for researchers who have never approached the study of viral ...
    • A candidate gene survey of quantitative trait loci affecting chemical composition in tomato fruit 

      Bermúdez, Luisa; Urias, Ursula; Milstein, D.; Kamenetzky, Laura; Asís, Ramón; Fernie, Alisdair R.; Van Sluys, M.A.; Carrari, Fernando; Rossi, Magdalena (Society for Experimental Biology, 2008-07)
      In tomato, numerous wild-related species have been demonstrated to be untapped sources of valuable genetic variability, including pathogen-resistance genes, nutritional, and industrial quality traits. From a collection of ...
    • A closed-tube loop-mediated isothermal amplification assay for the visual endpoint detection of Brucella spp. and Mycobacterium avium subsp. paratuberculosis 

      Trangoni, Marcos David; Gioffre, Andrea; Cravero, Silvio Lorenzo Pedro (Springer, 2017-06)
      LAMP (loop-mediated isothermal amplification) is an isothermal nucleic acid amplification technique that is characterized by its efficiency, rapidity, high yield of final product, robustness, sensitivity, and specificity, ...
    • A computational study of the interaction of the foot and mouth disease virus VP1 with monoclonal antibodies 

      Marrero Diaz De Villegas, Rubén; Rodríguez Limardo, Ramiro; Carrillo, Elisa Cristina; Konig, Guido Alberto; Turjanski, Adrián G. (Elsevier, 2015-10)
      Foot and mouth disease is caused by a non-enveloped virus (FMDV), which disposes several antigenic sites at the surface of their capsid proteins. The most relevant and immunodominant antigenic site of FMDV (site A or AnSA) ...
    • A Coxiella mutualist symbiont is essential to the development of rhipicephalus microplus 

      Garcia Guizzo, Melina; Parizi, Luís Fernando; Nunes, Rodrigo Dutra; Schama, Renata; Albano, Rodolpho M.; Tirloni, Lucas; Oldiges, Daiane Patrícia; Pilz Vieira, Ricardo; Cruz Oliveira, Wanderson Henrique; De Souza Leite, Milane; Gonzalez, Sergio Alberto; Farber, Marisa Diana; Martins, Orlando; Da Silva Vaz, Itabajara; Oliveira, Pedro L. (Nature Publishing Group, 2017-12)
      The cattle tick Rhipicephalus microplus is a hematophagous ectoparasite that causes important economic losses in livestock. Different species of ticks harbor a symbiont bacterium of the genus Coxiella. It was showed that ...
    • A fijivirus major viroplasm protein shows RNA-stimulated ATPase activity by adopting pentameric and hexameric assemblies of dimers 

      Llauger, Gabriela; Melero, Roberto; Monti, Demian Esteban; Sycz, Gabriela; Huck-Iriart, Cristian; Cerutti, Maria Laura; Klinke, Sebastián; Mikkelsen, Evelyn; Tijman, Ariel; Arranz, Rocío; Alfonso, Victoria; Arellano, Sofía Maité; Goldbaum, Fernando Alberto; Sterckx, Yann G. J.; Carazo, José María; Kaufman, Sergio B.; Dans, Pablo D.; Del Vas, Mariana; Otero, Lisandro H. (American Society for Microbiology, 2023-02)
      Fijiviruses replicate and package their genomes within viroplasms in a pro cess involving RNA-RNA and RNA-protein interactions. Here, we demonstrate that the 24 C-terminal residues (C-arm) of the P9-1 major viroplasm protein ...
    • A fungal protease named AsES triggers antiviral immune responses and effectively restricts virus infection in arabidopsis and Nicotiana benthamiana plants 

      Caro, Maria Del Pilar; Venturuzzi, Andrea Laura; Moschen, Sebastian Nicolas; Salazar, Sergio Miguel; Díaz Ricci, Juan Carlos; Asurmendi, Sebastian (Oxford University Press, 2022-04)
      Background and Aims: Plants have evolved complex mechanisms to fight against pathogens. Among these mechanisms, pattern-triggered immunity (PTI) relies on the recognition of conserved microbe- or pathogen-associated molecular ...
    • A novel pathogenic DICER1 gene variant is associated with hereditary multinodular goiter in an Argentine family as evidenced by clinical, biochemical and molecular genetic analysis 

      Targovnik, Héctor M.; Barh, Debmalya; Papendieck, Patricia; Adrover, Ezequiela; Gallo, Ariel M.; Chiesa, Ana; Marques Da Silva, Wanderson; Azevedo, Vasco; Rivolta, Carina M. (Springer, 2025-03)
      DICER1 syndrome is an autosomal-dominant disorder that results in malignant or benign tumors. A number of distinct pathogenic germline and somatic variants have been identified as causing multinodular goiter (MNG). The ...
    • A participatory surveillance of marsh deer (Blastocerus dichotomus) morbidity and mortality in Argentina: first results 

      Orozco, María Marcela; Argibay, Hernán Darío; Minatel, Leonardo; Guillemi, Eliana Carolina; Berra, Yanina; Schapira, Andrea; Di Nucci, Dante; Marcos, Andrea; Lois, Fernanda; Falzone, Martín; Farber, Marisa Diana (BMC, 2020-09)
      Background: In an era of unprecedented socio-ecological changes, managing wildlife health demands high-quality data collection and the engagement of local communities. Blastocerus dichotomus, the largest South American ...
    • A phenotypic characterization of two isolates of a multidrug-resistant outbreak strain of mycobacterium tuberculosis with opposite epidemiological fitness 

      Bei, Jinlong; Bigi, María Mercedes; Lima, Analía; Zhang, Qi; Blanco, Federico Carlos; López, Beatriz; Yu, Ting; Wang, Zhilin; Dai, Zhangyan; Chen, Zhuang; Cataldi, Angel Adrian; Sasiain, María del Carmen; Ritacco, Viviana; De la Barrera, Silvia Susana; Soria, Marcelo Abel; Durán, Rosario; Bigi, Fabiana (Hindawi, 2020-04)
      Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB ...
    • A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice 

      Montenegro, Valeria Noely; Jaramillo Ortiz, Jose; Paoletta, Martina; Gravisaco, María José; Del Medico Zajac, Maria Paula; Garanzini, Debora Patricia; Valenzano, Magali Nicole; Calamante, Gabriela; Wilkowsky, Silvina Elizabeth (Elsevier, 2022-09)
      In the intraerythrocytic protozoan parasites of the genus Babesia both innate and adaptive immune responses are necessary to confer protection against clinical disease. In particular, the adaptive immune response involves ...
    • A thermostable GH8 endoglucanase of Enterobacter sp. R1 is suitable for β- glucan deconstruction 

      Ontañon, Ornella Mailen; Ghio, Silvina; Marrero Diaz De Villegas, Rubén; Garrido, Mercedes Maria; Talia, Paola Mónica; Fehér, Csaba; Campos, Eleonora (Elsevier, 2019-11)
      Glycoside hydrolase family 8 (GH8) includes endoglucanases, lichenases, chitosanases and xylanases, which are essential for polysaccharides breakdown. In this work, we studied a thermally stable GH8 from the cellulose ...
    • A tomato tocopherol-binding protein sheds light on intracellular a-tocopherol metabolism in plants 

      Bermudez Salazar, Luisa; del Pozo, Talía; Lira, Bruno Silvestre; Godoy, Fabiana de; Boos, Irene; Romano, Cecilia; Previtali, Viola; Almeida, Juliana; Brehelin, Claire; Asis, Ramón; Quadrana, Leandro Daniel; Demarco, Diego; Alseekh, Saleh; Salinas Gamboa, Rigel; Perez-Flores, Laura; Dominguez, Pia Guadalupe; Rothan, Christophe; Fernie, Alisdair R.; Gonzalez, Maurıcio; Stocker, Achim; Hemmerle, Andreas; Clausen, Mads Hartving; Carrari, Fernando; Rossi, Magdalena (Oxford University Press, 2018-11)
      Tocopherols are non-polar compounds synthesized in the plastids, which function as major antioxidants of the plant cells and are essential in the human diet. Both the intermediates and final products of the tocopherol ...
    • A transcriptional analysis of cattle immune cells reveals a central role of type 1 interferon in the In vitro innate immune response against Mycobacterium bovis 

      Blanco, Federico Carlos; Bigi, María Mercedes; Garcia, Elizabeth Andrea; Elola, María Teresa; Vazquez, Cristina Lourdes; Bigi, Fabiana (MDPI, 2023-09)
      Bovine tuberculosis is a chronic infectious disease primarily caused by Mycobacterium bovis, a bacterium that affects cattle and other mammals, including humans. Despite the availability of vast research about the immune ...
    • A β-Hairpin Motif in the Envelope Protein E2 Mediates Receptor Binding of Bovine Viral Diarrhea Virus 

      Merwaiss, Fernando; Pascual, María José; Pomilio, María Trinidad; Lopez, Maria Gabriela; Taboga, Oscar Alberto; Alvarez, Diego Ezequiel (MDPI, 2021-06)
      Pestivirus envelope protein E2 is crucial to virus infection and accomplishes virus-receptor interaction during entry. However, mapping of E2 residues mediating these interactions has remained unexplored. In this study, ...
    • Achiote (Bixa orellana L.) : a natural source of pigment and vitamin E 

      Raddatz-Mota, Denise; Pérez Flores, Laura J.; Carrari, Fernando; Mendoza Espinoza, José Alberto; Díaz de León-Sánchez, Fernando; Pinzón-López, Luis L.; Godoy-Hernández, Gregorio; Rivera Cabrera, Fernando (Springer, 2017-05)
      Commercialization of agricultural products, including seeds and its derived products, represents an important economic source for developing countries. Natural colorants obtained from the seeds of achiote plant (annatto) ...
    • Acinetobacter baumannii and Its relationship to carbapenem resistance : a meta-analysis 

      Rodrigues, Diego Lucas Neres; Costa, Francielly Morais Rodrigues da; Marques Da Silva, Wanderson; Aburjaile, Flavia; Azevedo, Vasco (MDPI, 2022-05)
      Infections by antibiotic-resistant bacteria are a significant and complex global health issue. In this context, Acinetobacter baumannii is particularly important because of its ability to withstand treatments by β-lactams, ...
    • AcMNPV Core Gene ac109 Is Required for Budded Virion Transport to the Nucleus and for Occlusion of Viral Progeny 

      Alfonso, Victoria; Maroniche, Guillermo Andrés; Reca, Sol Rita; Lopez, Maria Gabriela; Del Vas, Mariana; Taboga, Oscar Alberto (Plos One, 2012-09)
      The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac109 core gene has been previously characterized as an essential late gene. Our results showed that budded virions could be detected in supernatants of ...
    • Agroinoculation of a full-length cDNA clone of cotton leafroll dwarf virus (CLRDV) results in systemic infection in cotton and the model plant Nicotiana benthamiana 

      Delfosse, Veronica Cecilia; Casse, Maria Florencia; Agrofoglio, Yamila Carla; Bonacic Kresic, Iván; Hopp, Horacio Esteban; Ziegler-Graff, Véronique; Distefano, Ana Julia (2013-07)
      Cotton blue disease is the most important viral disease of cotton in the southern part of South America. Its etiological agent, cotton leafroll dwarf virus (CLRDV), is specifically transmitted to host plants by the aphid ...